Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

Serine and glycine are biosynthetically linked, and together provide the essential precursors
for the synthesis of proteins, nucleic acids, and lipids that are crucial to cancer cell growth …

One-carbon metabolism involving the folate and methionine cycles integrates nutritional
status from amino acids, glucose and vitamins, and generates diverse outputs, such as the …

DNA methylation is an epigenetic mechanism that is essential for regulating gene
transcription. However, aberrant DNA methylation, which is a nearly universal finding in …

ABSTRACT DNA methylation is an epigenetic modification critical to normal genome
regulation and development. The vitamin folate is a key source of the one carbon group …

DNA methylation is the most extensively studied mechanism of epigenetic gene regulation.
Increasing evidence indicates that DNA methylation is labile in response to nutritional and …

Metabolic profiling of cancer cells has recently been established as a promising tool for the
development of therapies and identification of cancer biomarkers. Here we characterized the …

Colorectal cancer (CRC) is a heterogeneous disease in which unique subtypes are
characterized by distinct genetic and epigenetic alterations. Here we performed …

Alcohol consumption by adult women is consistently associated with risk of breast cancer.
Several questions regarding alcohol and breast cancer need to be addressed. Menarche to …

The study of normal mammalian cell growth and the defects that contribute to disease
pathogenesis links metabolism to cell growth. Here, we visit several aspects of growth …