The complicated interactions between Leishmania and the host antigen-presenting cells
(APCs) have fundamental effects on the final outcome of the disease. Two major APCs …

Sample preparation is one of the most important steps in metabolome analysis. The
challenges of determining microbial metabolome have been well discussed within the …

Leishmania, the causative agent of leishmaniases, is an intracellular parasite of
macrophages, transmitted to humans via the bite of its sand fly vector. This protozoan …

The discovery of molecules capable of presenting lipid antigens, the CD1 family, and of the
T cells that recognize them, has opened a new dimensionin our understanding of cell …

Leishmania parasites alternate between extracellular promastigote stages in the insect
vector and an obligate intracellular amastigote stage that proliferates within the …

Leishmaniasis is a zoonotic and vector-borne infectious disease that is caused by the genus
Leishmania belonging to the trypanosomatid family. The protozoan parasite has a digenetic …

The family Trypanosomatidae, flagellated parasitic protozoa, is responsible for important
infectious diseases in humans: slee** sickness, Chagas diseases and leishmaniasis …

Leishmania is a protozoan parasite that alternates its life cycle between the sand fly and the
mammalian host macrophages, involving several environmental changes. The parasite …

Polyamines (PAs) are essential metabolites in eukaryotes, participating in a variety of
proliferative processes, and in trypanosomatid protozoa play an additional role in the …

Leishmania spp. are sandfly-transmitted parasitic protozoa that cause a spectrum of
important diseases and lifelong chronic infections in humans. In the mammalian host, these …