Force-sensing biophysical cues in microenvironment, including extracellular matrix
performances, stretch-mediated mechanics, shear stress and flow-induced hemodynamics …

Nesprins (nuclear envelope spectrin repeat proteins) are multi-isomeric scaffolding proteins.
Giant nesprin-1 and-2 localise to the outer nuclear membrane, interact with SUN …

The mechanical properties of soft tissues can often be strongly correlated with the
progression of various diseases, such as myocardial infarction (MI). However, the dynamic …

One of the features of pathological cardiac hypertrophy is enhanced translation and protein
synthesis. Translational inhibition has been shown to be an effective means of treating …

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the most common cardiac genetic
disorder caused by sarcomeric gene variants and associated with left ventricular …

Organophosphorus flame retardants (OPFRs) such as triphenyl phosphate (TPHP) and tris
(1, 3-dichloro-2-propyl) phosphate (TDCIPP) were reported to impair cardiac function in fish …

Background The only clinically approved drug that reduces doxorubicin cardiotoxicity is
dexrazoxane, but its application is limited due to the risk of secondary malignancies. So …

Ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) are the two primary
etiologies of end-stage heart failure. However, there remains a dearth of comprehensive …

Microtubules (MTs) are essential for many cellular processes including establishment of cell
shape and polarity, chromosome segregation, vesicle transport, and nuclear positioning …

Cardiac fibrosis is a common pathology in cardiovascular diseases which are reported as
the leading cause of death globally. In recent decades, accumulating evidence has shown …