An ensemble penalized regression method for multi-ancestry polygenic risk prediction
Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve
the prediction of complex traits and diseases. However, most existing PRS are primarily …
the prediction of complex traits and diseases. However, most existing PRS are primarily …
MUSSEL: Enhanced Bayesian polygenic risk prediction leveraging information across multiple ancestry groups
Polygenic risk scores (PRSs) are now showing promising predictive performance on a wide
variety of complex traits and diseases, but there exists a substantial performance gap across …
variety of complex traits and diseases, but there exists a substantial performance gap across …
[PDF][PDF] Admix-kit: an integrated toolkit and pipeline for genetic analyses of admixed populations
Admixed populations, with their unique and diverse genetic backgrounds, are often
underrepresented in genetic studies. This oversight not only limits our understanding but …
underrepresented in genetic studies. This oversight not only limits our understanding but …
Ensembled best subset selection using summary statistics for polygenic risk prediction
Polygenic risk scores (PRS) enhance population risk stratification and advance
personalized medicine, yet existing methods face a tradeoff between predictive power and …
personalized medicine, yet existing methods face a tradeoff between predictive power and …