Mania has long been recognized as aberrant behaviour indicative of mental illness. Manic
states include a variety of complex and multifaceted symptoms that challenge clear clinical …

Intact function of the medial prefrontal cortex (mPFC) function relies on proper development
of excitatory and inhibitory neuronal populations and on integral myelination processes …

Maternal immune activation (MIA) during pregnancy represents an important environmental
factor in the etiology of schizophrenia and autism spectrum disorders (ASD). Our goal was to …

Antipsychotic sensitization and tolerance refer to the increased and decreased drug effects
due to past drug use, respectively. Both effects reflect the long-term impacts of antipsychotic …

Background The role of glutamatergic receptors in major depressive disorder continues to
be of great interest for therapeutic development. Recent studies suggest that both negative …

Schizophrenia is a major psychiatric disease that is characterized by three distinct symptom
domains: positive symptoms, negative symptoms, and cognitive impairment. Additionally …

Cognitive symptoms are core features of mental disorders but procognitive treatments are
limited. We have proposed a “discoordination” hypothesis that cognitive impairment results …

Previous work established that repeated olanzapine (OLZ) administration in normal
adolescent rats induces a sensitization effect (ie increased behavioral responsiveness to …

Objectives: The aim of this study was to investigate the effects of oral administration of a
novel benzodiazepine derivative, JM-20, on the neurological behavior of different rodent …

Brain-derived neurotrophic factor (BDNF) and STriatal-Enriched protein tyrosine
Phosphatase 61 (STEP 61) have opposing functions in the brain, with BDNF supporting and …