The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …

Obesity is among the most threatening health burdens worldwide and its prevalence has
markedly increased over the last decades. Obesity maybe considered a heritable trait …

Prior mouse genetic research has set the stage for a deep understanding of appetite
regulation. This goal is now being realized through the use of recent technological …

INTRODUCTION Loss-of-function mutations in one gene copy can lead to reduced amounts
of protein and, consequently, human disease, a condition termed haploinsufficiency. It is …

In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Under normal conditions, food intake and energy expenditure are balanced by a
homeostatic system that maintains stability of body fat content over time. However, this …

Obesity is a complex, heritable trait influenced by the interplay of genetics, epigenetics,
metagenomics and the environment. With the increasing access to high precision diagnostic …

The global rise in the prevalence of obesity and associated co-morbidities such as type 2
diabetes, cardiovascular disease, and cancer represents a major public health concern. The …

Hunger is a complex behavioural state that elicits intense food seeking and consumption.
These behaviours are rapidly recapitulated by activation of starvation-sensitive AGRP …

Obesity results from a synergistic relationship between genes and the environment. The
phenotypic expression of genetic factors involved in obesity is variable, allowing to …