Metformin and cancer: solutions to a real-world evidence failure

OHY Yu, S Suissa - Diabetes care, 2023 - Am Diabetes Assoc
The quest to repurpose metformin, an antidiabetes drug, as an agent for cancer prevention
and treatment, which began in 2005 with an observational study that reported a reduction in …

Identification of Parkinson's disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data

C Su, Y Hou, J Xu, Z Xu, M Zhou, A Ke, H Li, J Xu… - npj Digital …, 2024 - nature.com
Parkinson's disease (PD) is a serious neurodegenerative disorder marked by significant
clinical and progression heterogeneity. This study aimed at addressing heterogeneity of PD …

Architectural styles of curiosity in global Wikipedia mobile app readership

D Zhou, S Patankar, DM Lydon-Staley, P Zurn… - Science …, 2024 - science.org
Intrinsically motivated information seeking is an expression of curiosity believed to be central
to human nature. However, most curiosity research relies on small, Western convenience …

Exploring the impact mechanism of executives' environmental attention on corporate green transformation: evidence from the textual analysis of Chinese companies' …

X Ding, Z Xu, MV Petrovskaya, K Wu, L Ye… - … Science and Pollution …, 2023 - Springer
The allocation of executives' environmental attention (EEA) is of great significance in
promoting the green upgrading of industrial structures and achieving corporate green …

Real-world evidence of ocrelizumab-treated relapsing multiple sclerosis cohort shows changes in progression independent of relapse activity mirroring phase 3 trials

J Ingwersen, L Masanneck, M Pawlitzki… - Scientific Reports, 2023 - nature.com
Ocrelizumab is a B cell-depleting drug widely used in relapsing–remitting multiple sclerosis
(RRMS) and primary-progressive MS. In RRMS, it is becoming increasingly apparent that …

Assessing fairness in machine learning models: A study of racial bias using matched counterparts in mortality prediction for patients with chronic diseases

Y Wang, L Wang, Z Zhou, J Laurentiev, JR Lakin… - Journal of biomedical …, 2024 - Elsevier
Objective Existing approaches to fairness evaluation often overlook systematic differences in
the social determinants of health, like demographics and socioeconomics, among …

Artificial intelligence-based forensic sex determination of East Asian cadavers from skull morphology

H Kondou, R Morohashi, S Kimura, N Idota… - Scientific Reports, 2023 - nature.com
Identification of unknown cadavers is an important task for forensic scientists. Forensic
scientists attempt to identify skeletal remains based on factors including age, sex, and dental …

The impact mechanism of green credit policy on the sustainability performance of heavily polluting enterprises—based on the perspectives of technological innovation …

X Ding, R **g, K Wu, MV Petrovskaya, Z Li… - International Journal of …, 2022 - mdpi.com
Green credit policy (GCP), as one of the key financial instruments to achieve'carbon
peaking'and 'carbon neutrality'targets, provides capital support for the green development of …

A network-based systems genetics framework identifies pathobiology and drug repurposing in Parkinson's disease

L Dou, Z Xu, J Xu, C Zang, C Su, AA Pieper… - npj Parkinson's …, 2025 - nature.com
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder.
However, current treatments only manage symptoms and lack the ability to slow or prevent …

Word2vec word embedding-based artificial intelligence model in the triage of patients with suspected diagnosis of major ischemic stroke: a feasibility study

A Desai, A Zumbo, M Giordano, P Morandini… - International Journal of …, 2022 - mdpi.com
Background: The possible benefits of using semantic language models in the early
diagnosis of major ischemic stroke (MIS) based on artificial intelligence (AI) are still …