Antimicrobial resistance monitoring of water environments: a framework for standardized methods and quality control

K Liguori, I Keenum, BC Davis, J Calarco… - … science & technology, 2022 - ACS Publications
Antimicrobial resistance (AMR) is a grand societal challenge with important dimensions in
the water environment that contribute to its evolution and spread. Environmental monitoring …

[HTML][HTML] Towards the sustainable discovery and development of new antibiotics

M Miethke, M Pieroni, T Weber, M Brönstrup… - Nature Reviews …, 2021 - nature.com
An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

Antibiotic pollution in the environment: from microbial ecology to public policy

SA Kraemer, A Ramachandran, GG Perron - Microorganisms, 2019 - mdpi.com
The ability to fight bacterial infections with antibiotics has been a longstanding cornerstone
of modern medicine. However, wide-spread overuse and misuse of antibiotics has led to …

Conjugative plasmids interact with insertion sequences to shape the horizontal transfer of antimicrobial resistance genes

Y Che, Y Yang, X Xu, K Břinda… - Proceedings of the …, 2021 - National Acad Sciences
It is well established that plasmids play an important role in the dissemination of
antimicrobial resistance (AMR) genes; however, little is known about the role of the …

Heterotrophic nitrification and aerobic denitrification process: Promising but a long way to go in the wastewater treatment

H **, X Zhou, M Arslan, Z Luo, J Wei, Z Wu… - Science of The Total …, 2022 - Elsevier
The traditional biological nitrogen removal (BNR) follows the conventional scheme of
sequential nitrification and denitrification. In recent years, novel processes such as …

[HTML][HTML] Extracellular polymeric substances—antibiotics interaction in activated sludge: a review

W Zhao, J You, S Yin, H Yang, S He, L Feng, J Li… - Environmental Science …, 2023 - Elsevier
Antibiotics, the most frequently prescribed drugs, have been widely applied to prevent or
cure human and veterinary diseases and have undoubtedly led to massive releases into …

Long-read metagenomic sequencing reveals shifts in associations of antibiotic resistance genes with mobile genetic elements from sewage to activated sludge

D Dai, C Brown, H Bürgmann, DGJ Larsson, I Nambi… - Microbiome, 2022 - Springer
Background There is concern that the microbially rich activated sludge environment of
wastewater treatment plants (WWTPs) may contribute to the dissemination of antibiotic …

Seizing the moment: now is the time for integrated global surveillance of antimicrobial resistance in wastewater environments

A Pruden, PJ Vikesland, BC Davis… - Current Opinion in …, 2021 - Elsevier
Highlights•Environmental surveillance of AMR is missing from current One Health
strategies.•Integrated surveillance can benefit clinical practice and mitigate the spread of …

Microplastics as hubs enriching antibiotic-resistant bacteria and pathogens in municipal activated sludge

DN Pham, L Clark, M Li - Journal of Hazardous Materials Letters, 2021 - Elsevier
Microplastics can serve as carriers of antibiotic-resistant bacteria (ARB) and pathogens,
representing a pressing concern to aquatic biota and human health. Activated sludge units …

Mobile antibiotic resistome in wastewater treatment plants revealed by Nanopore metagenomic sequencing

Y Che, Y **a, L Liu, AD Li, Y Yang, T Zhang - Microbiome, 2019 - Springer
Abstract Background Wastewater treatment plants (WWTPs) are recognized as hotspots for
horizontal gene transfer (HGT) of antibiotic resistance genes (ARGs). Despite our …