Myeloid cell-targeted therapies for solid tumours
Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …
where they have a variety of functions, ranging from immunosuppressive to …
Myeloid immunosuppression and immune checkpoints in the tumor microenvironment
Tumor-promoting inflammation and the avoidance of immune destruction are hallmarks of
cancer. While innate immune cells, such as neutrophils, monocytes, and macrophages, are …
cancer. While innate immune cells, such as neutrophils, monocytes, and macrophages, are …
The role of phosphatidylserine recognition receptors in multiple biological functions
Apoptotic cells are rapidly engulfed and degraded by phagocytes through efferocytosis.
Efferocytosis is a highly regulated process. It is triggered upon the activation of caspase …
Efferocytosis is a highly regulated process. It is triggered upon the activation of caspase …
Cancer cell-derived type I interferons instruct tumor monocyte polarization
D Kwart, J He, S Srivatsan, C Lett, J Golubov… - Cell Reports, 2022 - cell.com
Monocytes are highly plastic immune cells that modulate antitumor immunity. Therefore,
identifying factors that regulate tumor monocyte functions is critical for develo** effective …
identifying factors that regulate tumor monocyte functions is critical for develo** effective …
Immunotherapeutic Blockade of Macrophage Clever-1 Reactivates the CD8+ T-cell Response against Immunosuppressive Tumors
M Viitala, R Virtakoivu, S Tadayon, J Rannikko… - Clinical Cancer …, 2019 - AACR
Purpose: As foremost regulators of cancer-related inflammation and immunotherapeutic
resistance, tumor-associated macrophages have garnered major interest as …
resistance, tumor-associated macrophages have garnered major interest as …
Immunotherapy that improves response to chemotherapy in high-grade serous ovarian cancer
Single-cell RNA sequencing (scRNAseq) of tumour-infiltrating immune cells in high-grade
serous ovarian cancer (HGSOC) omental biopsies reveals potential targets that could …
serous ovarian cancer (HGSOC) omental biopsies reveals potential targets that could …
New tools to prevent cancer growth and spread: a 'Clever'approach
Clever-1 (also known as Stabilin-1 and FEEL-1) is a scavenger receptor expressed on
lymphatic endothelial cells, sinusoidal endothelial cells and immunosuppressive monocytes …
lymphatic endothelial cells, sinusoidal endothelial cells and immunosuppressive monocytes …
[HTML][HTML] Novel outcome biomarkers identified with targeted proteomic analyses of plasma from critically ill coronavirus disease 2019 patients
Objectives: Coronavirus disease 2019 patients admitted to the ICU have high mortality. The
host response to coronavirus disease 2019 has only been partially elucidated, and …
host response to coronavirus disease 2019 has only been partially elucidated, and …
Systemic blockade of clever-1 elicits lymphocyte activation alongside checkpoint molecule downregulation in patients with solid tumors: results from a phase I/II …
R Virtakoivu, JH Rannikko, M Viitala, F Vaura… - Clinical Cancer …, 2021 - AACR
Purpose: Macrophages are critical in driving an immunosuppressive tumor
microenvironment that counteracts the efficacy of T-cell–targeting therapies. Thus, agents …
microenvironment that counteracts the efficacy of T-cell–targeting therapies. Thus, agents …
Macrophages and platelets in liver fibrosis and hepatocellular carcinoma
M Casari, D Siegl, C Deppermann… - Frontiers in …, 2023 - frontiersin.org
During fibrosis,(myo) fibroblasts deposit large amounts of extracellular matrix proteins,
thereby replacing healthy functional tissue. In liver fibrosis, this leads to the loss of …
thereby replacing healthy functional tissue. In liver fibrosis, this leads to the loss of …