GABAA receptors as targets for treating affective and cognitive symptoms of depression
In the past 20 years, our understanding of the pathophysiology of depression has evolved
from a focus on an imbalance of monoaminergic neurotransmitters to a multifactorial picture …
from a focus on an imbalance of monoaminergic neurotransmitters to a multifactorial picture …
Transition metal ions and neurotransmitters: coordination chemistry and implications for neurodegeneration
Neurodegeneration is characterized by a disturbance in neurotransmitter-mediated
signaling pathways. Recent studies have highlighted the significant role of transition metal …
signaling pathways. Recent studies have highlighted the significant role of transition metal …
Cell-type-specific effects of age and sex on human cortical neurons
Altered transcriptional and epigenetic regulation of brain cell types may contribute to
cognitive changes with advanced age. Using single-nucleus multi-omic DNA methylation …
cognitive changes with advanced age. Using single-nucleus multi-omic DNA methylation …
Depressive patient‐derived GABA interneurons reveal abnormal neural activity associated with HTR2C
K Lu, Y Hong, M Tao, L Shen, Z Zheng… - EMBO molecular …, 2023 - embopress.org
Major depressive disorder with suicide behavior (sMDD) is a severe mood disorder, bringing
tremendous burden to family and society. Although reduced gamma amino butyric acid …
tremendous burden to family and society. Although reduced gamma amino butyric acid …
The covariance environment defines cellular niches for spatial inference
A key challenge of analyzing data from high-resolution spatial profiling technologies is to
suitably represent the features of cellular neighborhoods or niches. Here we introduce the …
suitably represent the features of cellular neighborhoods or niches. Here we introduce the …
Astrocyte-secreted neurocan controls inhibitory synapse formation and function
Astrocytes strongly promote the formation and maturation of synapses by secreted proteins.
Several astrocyte-secreted synaptogenic proteins controlling excitatory synapse …
Several astrocyte-secreted synaptogenic proteins controlling excitatory synapse …
Identification and validation of oxidative stress and immune-related hub genes in Alzheimer's disease through bioinformatics analysis
S Li, J **ao, C Huang, J Sun - Scientific Reports, 2023 - nature.com
Alzheimer's disease (AD) is the leading cause of dementia in aged population. Oxidative
stress and neuroinflammation play important roles in the pathogenesis of AD. Investigation …
stress and neuroinflammation play important roles in the pathogenesis of AD. Investigation …
Somatostatin and somatostatin-containing interneurons—from plasticity to pathology
Despite the obvious differences in the pathophysiology of distinct neuropsychiatric diseases
or neurodegenerative disorders, some of them share some general but pivotal mechanisms …
or neurodegenerative disorders, some of them share some general but pivotal mechanisms …
[HTML][HTML] Alzheimer's disease and sleep disorders: a bidirectional relationship
J Chen, G Peng, B Sun - Neuroscience, 2024 - Elsevier
Alzheimer's disease (AD) is the most prevalent dementia, pathologically featuring abnormal
accumulation of amyloid-β (A β) and hyperphosphorylated tau, while sleep, divided into …
accumulation of amyloid-β (A β) and hyperphosphorylated tau, while sleep, divided into …
In-silico EEG biomarkers of reduced inhibition in human cortical microcircuits in depression
Reduced cortical inhibition by somatostatin-expressing (SST) interneurons has been
strongly associated with treatment-resistant depression. However, due to technical …
strongly associated with treatment-resistant depression. However, due to technical …