Cancers undergo sequential changes to proton (H+) concentration and sensing that are
consequences of the disease and facilitate its further progression. The impact of protonation …

Cellular and organism survival depends upon the regulation of pH, which is regulated by
highly specialized cell membrane transporters, the solute carriers (SLC)(For a …

The disposal of ammonia, the main proton buffer in the urine, is important for acid–base
homeostasis. Renal ammonia excretion is the predominant contributor to renal net acid …

Carbonic anhydrases (CAs), because they catalyze the interconversion of carbon dioxide
(CO2) and water into bicarbonate (HCO3−) and protons (H+), thereby influencing pH, are …

The cerebrospinal fluid (CSF) fills the brain ventricles and the subarachnoid space
surrounding the brain and spinal cord. The fluid compartment of the brain ventricles …

Acidosis is a chemical signature of the tumour microenvironment that challenges
intracellular pH homeostasis. The orchestrated activity of acid-base transporters of the solute …

Chronic kidney disease (CKD) is characterized by progressive reduction in kidney function
and treatments aiming at stabilizing or slowing its progression may avoid or delay the …

Background: Losing or donating a kidney is associated with risks of develo**
hypertension and albuminuria. Few studies address mechanisms or interventions. We …

A transport protein's turnover rate (TOR) is the maximum rate of substrate translocation
under saturating conditions. This parameter represents the number of transporting events …

Metabolic acidosis (MAc)—an extracellular pH (pHo) decrease caused by a [HCO3−] o
decrease at constant [CO2] o—usually causes intracellular pH (pHi) to fall. Here we …