Eosinophils as potential biomarkers in respiratory viral infections

I Macchia, V La Sorsa, F Urbani, S Moretti… - Frontiers in …, 2023 - frontiersin.org
Eosinophils are bone marrow-derived granulocytes that, under homeostatic conditions,
account for as much as 1-3% of peripheral blood leukocytes. During inflammation …

Regulatory T cells (Tregs) and COVID-19: unveiling the mechanisms, and therapeutic potentialities with a special focus on long COVID

M Dhawan, AA Rabaan, S Alwarthan, M Alhajri… - Vaccines, 2023 - mdpi.com
The COVID-19 pandemic has caused havoc all around the world. The causative agent of
COVID-19 is the novel form of the coronavirus (CoV) named SARS-CoV-2, which results in …

An aberrant immune–epithelial progenitor niche drives viral lung sequelae

H Narasimhan, IS Cheon, W Qian, SS Hu, T Parimon… - Nature, 2024 - nature.com
The long-term physiological consequences of respiratory viral infections, particularly in the
aftermath of the COVID-19 pandemic—termed post-acute sequelae of SARS-CoV-2 (PASC) …

The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches

R Gheorghita, I Soldanescu, A Lobiuc… - Frontiers in …, 2024 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has been
defined as the greatest global health and socioeconomic crisis of modern times. While most …

Pathophysiological, immunological, and inflammatory features of long COVID

K Bohmwald, B Diethelm-Varela… - Frontiers in …, 2024 - frontiersin.org
The COVID-19 pandemic continues to cause severe global disruption, resulting in significant
excess mortality, overwhelming healthcare systems, and imposing substantial social and …

Liquid biomarkers of macrophage dysregulation and circulating spike protein illustrate the biological heterogeneity in patients with post‐acute sequelae of COVID‐19

C Schultheiß, E Willscher, L Paschold… - Journal of Medical …, 2023 - Wiley Online Library
Post‐acute sequelae of COVID‐19 (PASC) are long‐term consequences of SARS‐CoV‐2
infection that can substantially impair the quality of life. Underlying mechanisms ranging …

Potential for early noninvasive COVID-19 detection using electronic-nose technologies and disease-specific VOC metabolic biomarkers

AD Wilson, LB Forse - Sensors, 2023 - mdpi.com
The established efficacy of electronic volatile organic compound (VOC) detection
technologies as diagnostic tools for noninvasive early detection of COVID-19 and related …

Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19

B Zhu, X Wei, H Narasimhan, W Qian, R Zhang… - Science …, 2023 - science.org
The relationship between diabetes and coronavirus disease 2019 (COVID-19) is
bidirectional: Although individuals with diabetes and high blood glucose (hyperglycemia) …

[HTML][HTML] Aggregate index of systemic inflammation (AISI), disease severity, and mortality in COVID-19: a systematic review and meta-analysis

A Zinellu, P Paliogiannis, AA Mangoni - Journal of Clinical Medicine, 2023 - mdpi.com
Combined indices of different haematological cell types appear to be particularly promising
for investigating the link between systemic inflammation and coronavirus disease 2019 …

Unraveling the enigma of long COVID: novel aspects in pathogenesis, diagnosis, and treatment protocols

AM Baig, S Rosko, B Jaeger, J Gerlach… - Inflammopharmacology, 2024 - Springer
Long COVID, now unmistakably identified as a syndromic entity encompassing a complex
spectrum of symptoms, demands immediate resolution of its elusive pathogenic …