Establishing and maintaining cell identity depends on the proper regulation of gene
expression, as specified by transcription factors and reinforced by epigenetic mechanisms …

Transcription factors are adaptor molecules that detect regulatory sequences in the DNA
and target the assembly of protein complexes that control gene expression. Yet much of the …

DNA hydroxymethylation and its mediated DNA demethylation are critical for multiple
cellular processes, for example, nuclear reprogramming, embryonic development, and many …

The discovery of cytosine hydroxymethylation (5hmC) suggested a simple means of
demethylating DNA and activating genes. Further experiments, however, unearthed an …

Salamanders have been hailed as champions of regeneration, exhibiting a remarkable
ability to regrow tissues, organs and even whole body parts, eg their limbs. As such …

A strong connection exists between the cell cycle and mechanisms required for executing
cell fate decisions in a wide-range of developmental contexts. Terminal differentiation is …

CCAAT/enhancer binding protein-α (C/EBPα) induces transdifferentiation of B cells into
macrophages at high efficiencies and enhances reprogramming into induced pluripotent …

Mammalian oocytes can reprogram differentiated somatic cells into a totipotent state through
somatic cell nuclear transfer (SCNT), which is known as cloning. Although many mammalian …

Pluripotent stem cells can differentiate into nearly all types of cells in the body. This unique
potential provides significant promise for cell-based therapies to restore tissues or organs …

Aging and age‐associated disease are a major medical and societal burden in need of
effective treatments. Cellular reprogramming is a biological process capable of modulating …