The power of plasticity—metabolic regulation of hepatic stellate cells

P Trivedi, S Wang, SL Friedman - Cell metabolism, 2021 - cell.com
Hepatic stellate cells (HSCs) are resident non-parenchymal liver pericytes whose plasticity
enables them to regulate a remarkable range of physiologic and pathologic responses. To …

Biological functions of RBP4 and its relevance for human diseases

JS Steinhoff, A Lass, M Schupp - Frontiers in physiology, 2021 - frontiersin.org
Retinol binding protein 4 (RBP4) is a member of the lipocalin family and the major transport
protein of the hydrophobic molecule retinol, also known as vitamin A, in the circulation …

Antioxidant potentials of vitamin A and carotenoids and their relevance to heart disease

VP Palace, N Khaper, Q Qin, PK Singal - Free Radical Biology and …, 1999 - Elsevier
Despite being one of the first vitamins to be discovered, the full range of biological activities
for vitamin A remains to be defined. Structurally similar to vitamin A, carotenoids are a group …

[HTML][HTML] The journey of human transthyretin: synthesis, structure stability, and catabolism

C Sanguinetti, M Minniti, V Susini, L Caponi… - Biomedicines, 2022 - mdpi.com
Transthyretin (TTR) is a homotetrameric protein mainly synthesised by the liver and the
choroid plexus whose function is to carry the thyroid hormone thyroxine and the retinol …

[HTML][HTML] Mechanisms of feedback regulation of vitamin A metabolism

C O'Connor, P Varshosaz, AR Moise - Nutrients, 2022 - mdpi.com
Vitamin A is an essential nutrient required throughout life. Through its various metabolites,
vitamin A sustains fetal development, immunity, vision, and the maintenance, regulation, and …

Transthyretin: a review from a structural perspective

JA Hamilton, MD Benson - Cellular and Molecular Life Sciences CMLS, 2001 - Springer
Transthyretin (formerly called prealbumin) plays important physiological roles as a
transporter of thyroxine and retinol-binding protein. X-ray structural studies have provided …

[HTML][HTML] Retinoids in health and disease: a role for hepatic stellate cells in affecting retinoid levels

MW Haaker, AB Vaandrager, JB Helms - Biochimica et Biophysica Acta …, 2020 - Elsevier
Vitamin A (retinol) is important for normal growth, vision and reproduction. It has a role in the
immune response and the development of metabolic syndrome. Most of the retinol present …

Adipocyte HSL is required for maintaining circulating vitamin A and RBP4 levels during fasting

JS Steinhoff, C Wagner, HE Dähnhardt, K Košić… - EMBO …, 2024 - embopress.org
Vitamin A (retinol) is distributed via the blood bound to its specific carrier protein, retinol-
binding protein 4 (RBP4). Retinol-loaded RBP4 is secreted into the circulation exclusively …

Transthyretin and familial amyloidotic polyneuropathy: recent progress in understanding the molecular mechanism of neurodegeneration

X Hou, MI Aguilar, DH Small - The FEBS journal, 2007 - Wiley Online Library
Familial amyloidotic polyneuropathy (FAP) is an inherited autosomal dominant disease that
is commonly caused by accumulation of deposits of transthyretin (TTR) amyloid around …

The transthyretin-retinol-binding protein complex

HL Monaco - Biochimica et Biophysica Acta (BBA)-Protein Structure …, 2000 - Elsevier
Transthyretin (TTR, formerly called prealbumin), one of the transporters of the hormone
thyroxine and the lipocalin retinol-binding protein (RBP), the specific carrier of the vitamin …