Hydrogen/Deuterium eXchange Mass Spectrometry (HDX-MS) is a rapidly evolving
technique for analyzing structural features and dynamic properties of proteins. It may stand …

This review summarizes our present view on the molecular pathogenesis of human (h) E3-
deficiency caused by a variety of genetic alterations with a special emphasis on the …

The interactions between residues in a protein tertiary structure can be studied effectively
using the approach of protein structure network (PSN). A PSN is a node-edge representation …

Melanoma, the most severe form of skin cancer, has poor prognosis and is resistant to
chemotherapy. Targeting cancer metabolism is a promising approach in cancer …

DLD is a key gene involved in “cuproptosis,” but its roles in tumor progression and immunity
remain unclear. Exploring the potential mechanisms and biological roles of DLD may …

Background The human mitochondrial alpha-ketoglutarate dehydrogenase complex
(hKGDHc) converts KG to succinyl-CoA and NADH. Malfunction of and reactive oxygen …

In human metabolism, pyruvate dehydrogenase complex (PDC) is one of the most intricate
and large multimeric protein systems representing a central hub for cellular homeostasis …

Herein are reported findings in vitro suggesting both functional and regulatory cross-talk
between the human 2-oxoglutarate dehydrogenase complex (hOGDHc), a key regulatory …

Human dihydrolipoamide dehydrogenase (hLADH, hE3) deficiency (OMIM# 246900) is an
often prematurely lethal genetic disease usually caused by inactive or partially inactive hE3 …

The human 2-oxoglutaric acid dehydrogenase complex (hOGDHc) plays a pivotal role in the
tricarboxylic acid (TCA) cycle, and its diminished activity is associated with …