Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery
drive cell division. Growing evidence indicates that this machinery operates in a distinct …

Neural stem cells in the adult mammalian brain are the source of new neurons that
contribute to complex sensory and cognitive functions. Most adult neural stem cells are …

Neurogenesis persists in adult mammals in specific brain areas, known as neurogenic
niches. Adult neurogenesis is highly dynamic and is modulated by multiple physiological …

Functional plasticity of the brain decreases during ageing causing marked deficits in
contextual learning, allocentric navigation and episodic memory. Adult neurogenesis is a …

Size and folding of the cerebral cortex increased massively during mammalian evolution
leading to the current diversity of brain morphologies. Various subtypes of neural stem and …

It was recently suggested that supplying the brain with new neurons could counteract
Alzheimer's disease (AD). This provocative idea requires further testing in experimental …

Abstract Tris (2-chloroisopropyl) phosphate (TCPP) and Tris (2-chloroethyl) phosphate
(TCEP) are the widely used organophosphorus flame retardants indoors and easily …

Neurogenesis, crucial for brain resilience, is reduced in Alzheimer's disease (AD) that
induces astroglial reactivity at the expense of the pro-neurogenic potential, and restoring …

Transcriptome analysis of somatic stem cells and their progeny is fundamental to identify
new factors controlling proliferation versus differentiation during tissue formation. Here, we …

Stem cell self-renewal, commitment and reprogramming rely on a poorly understood
coordination of cell cycle progression and execution of cell fate choices. Using existing …