Dual inhibition of TGF‐β and PD‐L1: a novel approach to cancer treatment
Transforming growth factor‐β (TGF‐β) and programmed death ligand 1 (PD‐L1) initiate
signaling pathways with complementary, nonredundant immunosuppressive functions in the …
signaling pathways with complementary, nonredundant immunosuppressive functions in the …
Transforming growth factor-β signaling in fibrotic diseases and cancer-associated fibroblasts
X Shi, CD Young, H Zhou, XJ Wang - Biomolecules, 2020 - mdpi.com
Transforming growth factor-β (TGF-β) signaling is essential in embryo development and
maintaining normal homeostasis. Extensive evidence shows that TGF-β activation acts on …
maintaining normal homeostasis. Extensive evidence shows that TGF-β activation acts on …
Extracellular matrices and cancer-associated fibroblasts: targets for cancer diagnosis and therapy?
I Belhabib, S Zaghdoudi, C Lac, C Bousquet, C Jean - Cancers, 2021 - mdpi.com
Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …
Remodelling of the tumour microenvironment by the kallikrein-related peptidases
Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment.
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …
KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including …
Cancer exosomes and natural killer cells dysfunction: biological roles, clinical significance and implications for immunotherapy
Tumor-derived exosomes (TDEs) play pivotal roles in several aspects of cancer biology. It is
now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity …
now evident that TDEs also favor tumor growth by negatively affecting anti-tumor immunity …
[HTML][HTML] Advances in dendritic cell vaccination therapy of cancer
S Najafi, K Mortezaee - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Traditionally, vaccines have helped eradication of several infectious diseases and also
saved millions of lives in the human history. Those prophylactic vaccines have acted through …
saved millions of lives in the human history. Those prophylactic vaccines have acted through …
The interactions of docetaxel with tumor microenvironment
R Gupta, MM Kadhim, AT Jalil, MQ Alasheqi… - International …, 2023 - Elsevier
There are several interactions within the tumor microenvironment (TME) that affect the
response of cancer cells to therapy. There are also a large number of cells and secretions in …
response of cancer cells to therapy. There are also a large number of cells and secretions in …
TGF-β signaling pathway: Therapeutic targeting and potential for anti-cancer immunity
Transforming growth factor-β (TGFβ) is a pleiotropic secretory cytokine exhibiting both
cancer-inhibitory and promoting properties. It transmits its signals via Suppressor of Mother …
cancer-inhibitory and promoting properties. It transmits its signals via Suppressor of Mother …
Cancer-associated fibroblasts in the hypoxic tumor microenvironment
Simple Summary Cancers have regions of low oxygen concentration where hypoxia-related
signaling pathways are activated. The hypoxic tumor microenvironment has been widely …
signaling pathways are activated. The hypoxic tumor microenvironment has been widely …
The transformation of cancer-associated fibroblasts: Current perspectives on the role of TGF-β in CAF mediated tumor progression and therapeutic resistance
Over the last few years, the Transforming growth factor-β (TGF-β) has been significantly
considered as an effective and ubiquitous mediator of cell growth. The cytokine, TGF-β is …
considered as an effective and ubiquitous mediator of cell growth. The cytokine, TGF-β is …