Deregulations of the expression of the S100A8 and S100A9 genes and/or proteins, as well
as changes in their plasma levels or their levels of secretion in the bone marrow …

Chemotherapy and targeted therapy can significantly improve survival rates in cancer, but
multiple drug resistance (MDR) limits the efficacy of these approaches. Understanding the …

Aberrant activation of NFκB orchestrates a critical role in tumor carcinogenesis; however, the
regulatory mechanisms underlying this activation are not fully understood. Here we report …

Purpose Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with
a dismal prognosis which is, among others, due to a lack of suitable biomarkers and …

Purpose Previously, compounds containing a piperidone structure have been shown to be
highly cytotoxic to cancer cells. Recently, we found that the piperidone compound P2 …

Acute lymphoblastic leukemia (ALL) is the most common kind of pediatric cancer. Although
the cure rates in ALL have significantly increased in developed countries, still 15–20% of …

As one common disease causing young people to die suddenly due to cardiac arrest,
arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disorder of heart muscle …

Background Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-
associated deaths worldwide. Although recent studies have proposed different biomarkers …

Background: Ankylosing spondylitis (AS) is a type of arthritis which can cause inflammation
in the vertebrae and joints between the spine and pelvis. However, our understanding of the …

Glucocorticoids (GC) are the foundation of the chemotherapy regimen in acute
lymphoblastic leukemia (ALL). However, resistance to GC is observed more frequently than …