The P2X7 receptor in inflammatory diseases: angel or demon?
LEB Savio, P de Andrade Mello… - Frontiers in …, 2018 - frontiersin.org
Under physiological conditions, adenosine triphosphate (ATP) is present at low levels in the
extracellular milieu, being massively released by stressed or dying cells. Once outside the …
extracellular milieu, being massively released by stressed or dying cells. Once outside the …
P2X7 in cancer: from molecular mechanisms to therapeutics
R Lara, E Adinolfi, CA Harwood, M Philpott… - Frontiers in …, 2020 - frontiersin.org
P2X7 is a transmembrane receptor expressed in multiple cell types including neurons,
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …
dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of …
Blocking antibodies targeting the CD39/CD73 immunosuppressive pathway unleash immune responses in combination cancer therapies
I Perrot, HA Michaud, M Giraudon-Paoli, S Augier… - Cell reports, 2019 - cell.com
Immune checkpoint inhibitors have revolutionized cancer treatment. However, many cancers
are resistant to ICIs, and the targeting of additional inhibitory signals is crucial for limiting …
are resistant to ICIs, and the targeting of additional inhibitory signals is crucial for limiting …
First-in-human study of oleclumab, a potent, selective anti-CD73 monoclonal antibody, alone or in combination with durvalumab in patients with advanced solid …
J Bendell, P LoRusso, M Overman, AM Noonan… - Cancer Immunology …, 2023 - Springer
Background CD73 upregulation in tumors leads to local immunosuppression. This phase I,
first-in-human study evaluated oleclumab (MEDI9447), an anti-CD73 human IgG1λ …
first-in-human study evaluated oleclumab (MEDI9447), an anti-CD73 human IgG1λ …
Antibody to CD137 Activated by Extracellular Adenosine Triphosphate Is Tumor Selective and Broadly Effective In Vivo without Systemic Immune Activation
M Kamata-Sakurai, Y Narita, Y Hori, T Nemoto… - Cancer discovery, 2021 - AACR
Agonistic antibodies targeting CD137 have been clinically unsuccessful due to systemic
toxicity. Because conferring tumor selectivity through tumor-associated antigen limits its …
toxicity. Because conferring tumor selectivity through tumor-associated antigen limits its …
Purinergic signaling in the hallmarks of cancer
AR Campos-Contreras, M Díaz-Muñoz… - Cells, 2020 - mdpi.com
Cancer is a complex expression of an altered state of cellular differentiation associated with
severe clinical repercussions. The effort to characterize this pathological entity to understand …
severe clinical repercussions. The effort to characterize this pathological entity to understand …
Mast cell–tumor interactions: molecular mechanisms of recruitment, intratumoral communication and potential therapeutic targets for tumor growth
Mast cells (MCs) are tissue-resident immune cells that are important players in diseases
associated with chronic inflammation such as cancer. Since MCs can infiltrate solid tumors …
associated with chronic inflammation such as cancer. Since MCs can infiltrate solid tumors …
Challenges to the broad application of allogeneic natural killer cell immunotherapy of cancer
PR Kennedy, M Felices, JS Miller - Stem Cell Research & Therapy, 2022 - Springer
Natural killer (NK) cells are innate immune cells that recognize malignant cells through a
wide array of germline-encoded receptors. Triggering of activating receptors results in …
wide array of germline-encoded receptors. Triggering of activating receptors results in …
The yin and yang functions of extracellular ATP and adenosine in tumor immunity
L Feng, Y Cai, M Zhu, L **ng, X Wang - Cancer cell international, 2020 - Springer
Extracellular adenosine triphosphate (eATP) and its main metabolite adenosine (ADO)
constitute an intrinsic part of immunological network in tumor immunity. The concentrations …
constitute an intrinsic part of immunological network in tumor immunity. The concentrations …
New insight into the effects of metformin on diabetic retinopathy, aging and cancer: nonapoptotic cell death, immunosuppression, and effects beyond the AMPK …
SK Hsu, KC Cheng, MO Mgbeahuruike, YH Lin… - International Journal of …, 2021 - mdpi.com
Under metabolic stress conditions such as hypoxia and glucose deprivation, an increase in
the AMP: ATP ratio activates the AMP-activated protein kinase (AMPK) pathway, resulting in …
the AMP: ATP ratio activates the AMP-activated protein kinase (AMPK) pathway, resulting in …