Obesity and diabetes have both been associated with an increased risk of cancer. In the
face of increasing obesity and diabetes rates worldwide, this is a worrying trend for cancer …

OBJECTIVE Time-related biases in observational studies of drug effects have been
described extensively in different therapeutic areas but less so in diabetes. Immortal time …

Laboratory research and pharmacoepidemiology are providing converging evidence that
the widely used antidiabetic drug metformin has antineoplastic activity, but there are …

Biguanides have been developed for the treatment of hyperglycemia and type 2 diabetes.
Recently, metformin, the most widely prescribed biguanide, has emerged as a potential …

Purpose Type 2 diabetes mellitus (T2DM) is becoming increasingly prevalent worldwide.
Epidemiologic data suggest that T2DM is associated with an increased incidence and …

The antidiabetic drug metformin exerts chemopreventive and antineoplastic effects in many
types of malignancies. However, the mechanisms responsible for metformin actions appear …

Prevention of cancer remains the most promising strategy for reducing both its incidence
and the mortality due to this disease. For more than four decades, findings from …

Overweight and obesity have reached pandemic levels on a worldwide basis and are
associated with increased risk and worse prognosis for many but not all malignancies …

Metformin is the most commonly prescribed drug for type 2 diabetes (T2DM). Retrospective
studies show that metformin is associated with decreased cancer risk. This historical …

Healthy individuals can harbour microscopic tumours and dysplastic foci in different organs
in an undetectable and asymptomatic state for many years. These lesions do not progress in …