Cancer is a disease of the genome caused by oncogene activation and tumor suppressor
gene inhibition. Deep sequencing studies including large consortia such as TCGA and …

It is well known that phenotype of animals may be modified by the nutritional modulations
through epigenetic mechanisms. As a key and central component of epigenetic network …

Background During the process of spermatogenesis, male germ cells undergo dramatic
chromatin reorganization, whereby most histones are replaced by protamines, as part of the …

Allele-specific expression of imprinted gene clusters is governed by gametic DNA
methylation at master regulators called imprinting control regions (ICRs). Non-gametic or …

Background Environmental perturbation of epigenetic mechanisms is linked to a growing
number of diseases. Characterizing the role environmental factors play in modifying the …

Cyclin-dependent kinase (CDK)-inhibitor 1C (CDKN1C) negatively regulates cellular
proliferation and it has been shown that loss-of-function mutations in the imprinted CDKN1C …

Objective Macrosomia is one of the most common complications in gestational diabetes
mellitus. Insulin-like growth factor 2 and H19 are two of the imprinted candidate genes that …

Genomic imprinting, a phenomenon in which the two parental alleles are regulated
differently, is observed in mammals, marsupials and a few other species, including seed …

Different classes of non-coding RNA (ncRNA) influence the organization of chromatin.
Imprinted gene domains constitute a paradigm for exploring functional long ncRNAs …

Genomic imprinting gives rise to parent-of-origin dependent allelic gene expression. Most
imprinted genes cluster in domains where differentially methylated regions (DMRs) …