With over thirty different hormones identified as being produced in the gastrointestinal (GI)
tract, the gut has been described as 'the largest endocrine organ in the body'(Ann. Oncol …

For over 30 yr, it has been known that enteroendocrine cells derive from common precursor
cells in the intestinal crypts. Until recently, relatively little was understood about the events …

Gastric cancer has reduced prevalence, but poor prognoses. To improve treatment, better
knowledge of carcinogenesis and cells of origin should be sought. Stomach cancers are …

The 28th edition of Bailey & Love's Short Practice of Surgery is the leading surgical resource
for medical students and surgeons in training. It encompasses the basic principles of careful …

Background Recent data demonstrate that the incidence of gastroenteropancreatic
neuroendocrine tumors (GEP-NETs) has increased exponentially (overall~ 500%) over the …

Turnover of the epithelial cell lineages within the gastrointestinal tract is a constant process,
occurring every 2–7 days under normal homeostasis and increasing after damage. This …

Purpose The occurrence of≥ two distinct types of tumors, one of them paraganglioma
(PGL), is unusual in an individual patient, except in hereditary cancer syndromes. Patients …

Carcinoid tumors are rare, indolent neoplasms that, although clinically well defined, are
regarded as exotic and are consequently often unrecognized. Although little is known of the …

Congenital hypothyroidism is mainly due to structural defects of the thyroid gland,
collectively known as thyroid dysgenesis. The two most prevalent forms of this condition are …

Background: The neural crest contains pluripotent cells that can give rise to neurons and
glial cells of the peripheral nervous system, endocrine cells, connective tissue cells, muscle …