[HTML][HTML] Sustained proliferation in cancer: Mechanisms and novel therapeutic targets
Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …
[HTML][HTML] From NASH to diabetes and from diabetes to NASH: mechanisms and treatment options
A Gastaldelli, K Cusi - JHEP reports, 2019 - Elsevier
The worldwide prevalence of non-alcoholic fatty liver disease (NAFLD) is estimated to have
reached 25% or more in adults. NAFLD is prevalent in obese individuals, but may also affect …
reached 25% or more in adults. NAFLD is prevalent in obese individuals, but may also affect …
[HTML][HTML] A position statement on NAFLD/NASH based on the EASL 2009 special conference
V Ratziu, S Bellentani, H Cortez-Pinto… - Journal of …, 2010 - journal-of-hepatology.eu
Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are
increasingly relevant public health issues owing to their close association with the …
increasingly relevant public health issues owing to their close association with the …
Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
The worldwide rising prevalence of obesity and insulin resistance is associated with a
parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by …
parallel increase in nonalcoholic fatty liver disease (NAFLD). NAFLD is characterized by …
Parabacteroides distasonis uses dietary inulin to suppress NASH via its metabolite pentadecanoic acid
Non-alcoholic steatohepatitis (NASH) is the severe form of non-alcoholic fatty liver disease,
and is characterized by liver inflammation and fat accumulation. Dietary interventions, such …
and is characterized by liver inflammation and fat accumulation. Dietary interventions, such …
The subtle balance between lipolysis and lipogenesis: a critical point in metabolic homeostasis
Excessive accumulation of lipids can lead to lipotoxicity, cell dysfunction and alteration in
metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas …
metabolic pathways, both in adipose tissue and peripheral organs, like liver, heart, pancreas …
Gasdermin D plays a key role as a pyroptosis executor of non-alcoholic steatohepatitis in humans and mice
B Xu, M Jiang, Y Chu, W Wang, D Chen, X Li… - Journal of …, 2018 - Elsevier
Background & Aims Gasdermin D (GSDMD)-executed programmed necrosis is involved in
inflammation and controls interleukin (IL)-1β release. However, the role of GSDMD in non …
inflammation and controls interleukin (IL)-1β release. However, the role of GSDMD in non …
NAFLD, insulin resistance, and diabetes mellitus type 2
M Marušić, M Paić, M Knobloch… - Canadian Journal of …, 2021 - Wiley Online Library
Nonalcoholic fatty liver disease is a condition defined by fat accumulation in hepatocytes not
promoted by excessive alcohol consumption. It is highly prevalent and is strongly associated …
promoted by excessive alcohol consumption. It is highly prevalent and is strongly associated …
Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1β in mice
K Miura, Y Kodama, S Inokuchi, B Schnabl, T Aoyama… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Development of nonalcoholic steatohepatitis (NASH) involves the
innate immune system and is mediated by Kupffer cells and hepatic stellate cells (HSCs) …
innate immune system and is mediated by Kupffer cells and hepatic stellate cells (HSCs) …
[HTML][HTML] Animal models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
Y Takahashi, Y Soejima, T Fukusato - World journal of …, 2012 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in
the liver of a patient without a history of alcohol abuse. Nonalcoholic steatohepatitis (NASH) …
the liver of a patient without a history of alcohol abuse. Nonalcoholic steatohepatitis (NASH) …