Chromatin-state discovery and genome annotation with ChromHMM
Noncoding DNA regions have central roles in human biology, evolution, and disease.
ChromHMM helps to annotate the noncoding genome using epigenomic information across …
ChromHMM helps to annotate the noncoding genome using epigenomic information across …
Emerging roles of Wnt ligands in human colorectal cancer
X Nie, H Liu, L Liu, YD Wang, WD Chen - Frontiers in oncology, 2020 - frontiersin.org
Colorectal cancer (CRC) is the fourth leading cause of cancer death worldwide, and
constitutive activation of the Wnt signaling pathway is universal in most CRC cases. Wnt …
constitutive activation of the Wnt signaling pathway is universal in most CRC cases. Wnt …
Discovery of common and rare genetic risk variants for colorectal cancer
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …
genome sequencing of 1,439 cases and 720 controls, imputed discovered sequence …
Determining risk of colorectal cancer and starting age of screening based on lifestyle, environmental, and genetic factors
Background & Aims Guidelines for initiating colorectal cancer (CRC) screening are based
on family history but do not consider lifestyle, environmental, or genetic risk factors. We …
on family history but do not consider lifestyle, environmental, or genetic risk factors. We …
[HTML][HTML] Colon cancer: from epidemiology to prevention
Colorectal cancer (CRC) is one of the most prevalent cancers affecting humans, with a
complex genetic and environmental aetiology. Unlike cancers with known environmental …
complex genetic and environmental aetiology. Unlike cancers with known environmental …
Whole-genome sequencing of a healthy aging cohort
Studies of long-lived individuals have revealed few genetic mechanisms for protection
against age-associated disease. Therefore, we pursued genome sequencing of a related …
against age-associated disease. Therefore, we pursued genome sequencing of a related …
Epigenome-based cancer risk prediction: rationale, opportunities and challenges
The incidence of cancer is continuing to rise and risk-tailored early diagnostic and/or primary
prevention strategies are urgently required. The ideal risk-predictive test should: integrate …
prevention strategies are urgently required. The ideal risk-predictive test should: integrate …
Association analyses identify 31 new risk loci for colorectal cancer susceptibility
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a
strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases …
strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases …
LncRNAs with miRNAs in regulation of gastric, liver, and colorectal cancers: updates in recent years
Long noncoding RNA (lncRNA) is a kind of RNAi molecule composed of hundreds to
thousands of nucleotides. There are several major types of functional lncRNAs which …
thousands of nucleotides. There are several major types of functional lncRNAs which …
[HTML][HTML] Estimation of absolute risk of colorectal cancer based on healthy lifestyle, genetic risk, and colonoscopy status in a population-based study
Background & Aims Estimates of absolute risk of colorectal cancer (CRC) are needed to
facilitate communication and better inform the public about the potentials and limits of cancer …
facilitate communication and better inform the public about the potentials and limits of cancer …