The study of eukaryotic tRNA processing has given rise to an explosion of new information
and insights in the last several years. We now have unprecedented knowledge of each step …

tRNA biology has come of age, revealing an unprecedented level of understanding and
many unexpected discoveries along the way. This review highlights new findings on the …

Summary tRNAs are synthesized as immature precursors, and on their way to functional
maturity, extra nucleotides at their 5′ ends are removed by an endonuclease called RNase …

Although various functions of RNA are carried out in conjunction with proteins, some
catalytic RNAs, or ribozymes, which contribute to a range of cellular processes, require little …

West Nile virus (WNV) is an arthropod-borne, positive-sense RNA virus that poses an
increasing global threat due to warming climates and lack of effective therapeutics. Like …

Canonical microRNA biogenesis requires the Microprocessor components, Drosha and
DGCR8, to generate precursor-miRNA, and Dicer to form mature miRNA. The …

Nuclear ribonuclease (RNase) P is a ubiquitous essential ribonucleoprotein complex, one of
only two known RNA-based enzymes found in all three domains of life. The RNA component …

The ubiquitous endonuclease RNase P is responsible for the 5′ maturation of tRNA
precursors. Until the discovery of human mitochondrial RNase P, these enzymes had …

Mature tRNA is normally extensively modified and extremely stable. Recent evidence
suggests that hypomodified mature tRNA in yeast can undergo a quality control check by a …

Ribonuclease (RNase) P is a ubiquitous ribozyme that cleaves the 5′ leader from
precursor tRNAs. Here, we report cryo-electron microscopy structures of the human nuclear …