Foldamers as versatile frameworks for the design and evolution of function
Foldamers are sequence-specific oligomers akin to peptides, proteins and oligonucleotides
that fold into well-defined three-dimensional structures. They offer the chemical biologist a …
that fold into well-defined three-dimensional structures. They offer the chemical biologist a …
Design of Stimuli‐Responsive Peptides and Proteins
Stimuli‐responsive peptides and proteins are an exciting class of smart biomaterials for
various applications and have received significant attention over the past decades. A wide …
various applications and have received significant attention over the past decades. A wide …
Cyclic Poly(α-peptoid)s and Their Block Copolymers from N-Heterocyclic Carbene-Mediated Ring-Opening Polymerizations of N-Substituted N-Carboxylanhydrides
N-Heterocyclic carbene (NHC)-mediated ring-opening polymerization (ROP) of N-
substituted N-carboxylanhydride (N R-NCA) yields cyclic poly (α-peptoid) s with controlled …
substituted N-carboxylanhydride (N R-NCA) yields cyclic poly (α-peptoid) s with controlled …
Polypeptoid materials: current status and future perspectives
Polypeptoids have recently emerged as a subject of scientific interest due to their structural
resemblance to existing pseudo-peptidic polymers including poly (α-peptide) s, poly (β …
resemblance to existing pseudo-peptidic polymers including poly (α-peptide) s, poly (β …
Solid-Phase Synthesis of N-Substituted Glycine Oligomers (α-Peptoids) and Derivatives
AS Culf, RJ Ouellette - Molecules, 2010 - mdpi.com
Peptoids (N-substituted polyglycines and extended peptoids with variant backbone amino-
acid monomer units) are oligomeric synthetic polymers that are becoming a valuable …
acid monomer units) are oligomeric synthetic polymers that are becoming a valuable …
N-Heterocyclic Carbene-Mediated Zwitterionic Polymerization of N-Substituted N-Carboxyanhydrides toward Poly(α-peptoid)s: Kinetic, Mechanism, and Architectural …
L Guo, SH Lahasky, K Ghale… - Journal of the American …, 2012 - ACS Publications
N-Heterocyclic carbene (NHC)-mediated polymerizations of N-butyl N-carboxyanhydride
(Bu-NCA) to produce cyclic poly (N-butyl glycine) s (c-NHC-PNBGs) have been investigated …
(Bu-NCA) to produce cyclic poly (N-butyl glycine) s (c-NHC-PNBGs) have been investigated …
Cis–Trans Amide Bond Rotamers in β-Peptoids and Peptoids: Evaluation of Stereoelectronic Effects in Backbone and Side Chains
JS Laursen, J Engel-Andreasen, P Fristrup… - Journal of the …, 2013 - ACS Publications
Non-natural peptide analogs have significant potential for the development of new materials
and pharmacologically active ligands. One such architecture, the β-peptoids (N-alkyl-β …
and pharmacologically active ligands. One such architecture, the β-peptoids (N-alkyl-β …
β-Peptoid foldamers at last
JS Laursen, J Engel-Andreasen… - Accounts of Chemical …, 2015 - ACS Publications
Conspectus For a long time, peptides were considered unsuitable for drug development due
to their inherently poor pharmacokinetic properties and proteolytic susceptibility. However …
to their inherently poor pharmacokinetic properties and proteolytic susceptibility. However …
A preliminary survey of the peptoid folding landscape
We present an analysis of the conformational preferences of N-substituted glycine peptoid
oligomers. We survey the backbone conformations observed in experimentally determined …
oligomers. We survey the backbone conformations observed in experimentally determined …
Thermoresponsive poly (α-peptoid) s: tuning the cloud point temperatures by composition and architecture
SH Lahasky, X Hu, D Zhang - ACS Macro Letters, 2012 - ACS Publications
Random copolymers based on poly (N-ethyl glycine) and poly (N-butyl glycine) have been
synthesized by NHC-mediated or primary amine-initiated copolymerization of the …
synthesized by NHC-mediated or primary amine-initiated copolymerization of the …