Microglia are integral mediators of innate immunity within the mammalian central nervous
system. Typical microglial responses are transient, intending to restore homeostasis by …

Blood-brain barrier disruption plays an important role in central nervous system diseases.
This review provides information on the role of mitochondrial oxidative stress in brain …

Microglia are emerging as key drivers of neurological diseases. However, we lack a
systematic understanding of the underlying mechanisms. Here, we present a screening …

Brain imaging genomics is an emerging data science field, where integrated analysis of
brain imaging and genomics data, often combined with other biomarker, clinical, and …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by
cognitive decline, robust microgliosis, neuroinflammation, and neuronal loss. Genome-wide …

Recent genetic studies on Alzheimer's disease (AD) have brought microglia under the
spotlight, as loci associated with AD risk are enriched in genes expressed in microglia …

Introduction The inositol polyphosphate‐5‐phosphatase D (INPP5D) gene encodes a dual‐
specificity phosphatase that can dephosphorylate both phospholipids and phosphoproteins …

Abstract Background Recent DNA/RNA sequencing and other multi-omics technologies
have advanced the understanding of the biology and pathophysiology of AD, yet there is still …

Dementia is an umbrella term used to describe deterioration of cognitive function. It is the
seventh leading cause of death and is one of the major causes of dependence among older …

The genetic associations of TREM2 loss-of-function variants with Alzheimer disease (AD)
indicate the protective roles of microglia in AD pathogenesis. Functional deficiencies of …