The nodes of Ranvier have clustered Na+ and K+ channels necessary for rapid and efficient
axonal action potential conduction. However, detailed mechanisms of channel clustering …

In the central nervous system, oligodendrocytes produce myelin sheaths that enwrap
neuronal axons to provide trophic support and increase conduction velocity. New …

To enable rapid propagation of action potentials, axons are ensheathed by myelin, a
multilayered insulating membrane formed by oligodendrocytes. Most of the myelin is …

Although macroautophagy deficits are implicated across adult-onset neurodegenerative
diseases, we understand little about how the discrete, highly evolved cell types of the central …

The myelination of axons has evolved to enable fast and efficient transduction of electrical
signals in the vertebrate nervous system. Acting as an electric insulator, the myelin sheath is …

Objective Multiple sclerosis (MS) is a chronic neuroinflammatory and neurodegenerative
disease of unknown etiology. Although the prevalent view regards a CD4+‐lymphocyte …

Cell-surface expressed contactin 1 and neurofascin 155 control wiring of the nervous system
and interact across cells to form and maintain paranodal myelin-axon junctions. The …

Building a functional nervous system requires the coordinated actions of many glial cells. In
the vertebrate central nervous system (CNS), oligodendrocytes myelinate neuronal axons to …

One ubiquitous cellular structure for performing various tasks, such as spreading and
migration over external surfaces, is the sheet-like protrusion called a lamellipodium, which …

Myelin, which is produced by oligodendrocytes, insulates axons to facilitate rapid and
efficient action potential propagation in the central nervous system. Traditionally viewed as a …