Rotavirus is a major pathogen of infantile gastroenteritis. It is a large and complex virus with
a multilayered capsid organization that integrates the deter minants of host specificity, cell …

The ongoing pandemic of global concern has killed about three million humans and affected
around 151 million people worldwide, as of April 30, 2021. Although recently approved …

Hepatitis B virus (HBV) causes acute and chronic hepatitis and hepatocellular carcinoma.
Although a preventive vaccine is available, the therapeutic options for chronically infected …

The morphogenesis of rotaviruses follows a unique pathway in which immature double-
layered particles (DLPs) assembled in the cytoplasm bud across the membrane of the …

Initiation is the rate-limiting step in protein synthesis and therefore an important target for
regulation. For the initiation of translation of most cellular mRNAs, the cap structure at the …

The field of directed RNA interference (RNAi) has rapidly developed into a highly promising
approach for specifically downregulating genes to alleviate disease pathology. This …

Rotavirus morphogenesis starts in intracellular inclusion bodies called viroplasms. RNA
replication and packaging are mediated by several viral proteins, of which VP1, the RNA …

Rotavirus RRV gene 11 encodes two non-structural proteins, NSP5 and NSP6. NSP5 is a
phosphorylated non-structural protein that binds single-and double-stranded RNA in a non …

Human rotaviruses are the utmost etiologic agents of infantile gastroenteritis in children
under five years of age. To reduce childhood morbidity and mortality caused by this rotavirus …

Polylactide (PLA) and polylactide-co-glycolide (PLGA) particles entrap** rotavirus (strain
SA11) were formulated using a solvent evaporation technique. To minimize denaturation of …