This white paper discusses prospects for advancing hyperpolarization technology to better
understand cancer metabolism, identify current obstacles to HP (hyperpolarized) 13 C …

Hyperpolarized (HP) carbon 13 (13C) MRI is an emerging molecular imaging method that
allows rapid, noninvasive, and pathway-specific investigation of dynamic metabolic and …

The acidic tumour microenvironment is now recognized as a tumour phenotype that drives
cancer somatic evolution and disease progression, causing cancer cells to become more …

Metastasis is a multistep process that culminates in the spread of cells from a primary tumor
to a distant site or organs. For tumor cells to be able to metastasize, they have to locally …

Dynamic nuclear polarization is an emerging technique for increasing the sensitivity of
magnetic resonance imaging and spectroscopy, particularly for low‐γ nuclei. The technique …

Hyperpolarized magnetic resonance allows for noninvasive measurements of biochemical
reactions in vivo. Although this technique provides a unique tool for assaying enzymatic …

Simple Summary Cancer cells often show high levels of use of glucose, leading to acidic
conditions around tumors. This acidity can make cancer more aggressive, spreading to other …

Highly sensitive MR imaging agents that can accurately and rapidly monitor changes in pH
would have diagnostic and prognostic value for many diseases. Here, we report an …

This article describes the basic physics of dissolution dynamic nuclear polarization
(dissolution‐DNP), and the impact of the resulting highly nonequilibrium spin states, on the …

The term diabetic cardiomyopathy is defined as the presence of abnormalities in myocardial
structure and function that occur in the absence of, or in addition to, well-established …