A guide to the organ-on-a-chip
Abstract Organs-on-chips (OoCs) are systems containing engineered or natural miniature
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …
tissues grown inside microfluidic chips. To better mimic human physiology, the chips are …
Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning
SA Langhans - Frontiers in pharmacology, 2018 - frontiersin.org
Drug development is a lengthy and costly process that proceeds through several stages
from target identification to lead discovery and optimization, preclinical validation and …
from target identification to lead discovery and optimization, preclinical validation and …
Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting
The functional maturation and preservation of hepatic cells derived from human induced
pluripotent stem cells (hiPSCs) are essential to personalized in vitro drug screening and …
pluripotent stem cells (hiPSCs) are essential to personalized in vitro drug screening and …
Microfluidic organs-on-chips
An organ-on-a-chip is a microfluidic cell culture device created with microchip manufacturing
methods that contains continuously perfused chambers inhabited by living cells arranged to …
methods that contains continuously perfused chambers inhabited by living cells arranged to …
3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling
Abstract 3D bioprinting is emerging as a promising technology for fabricating complex tissue
constructs with tailored biological components and mechanical properties. Recent advances …
constructs with tailored biological components and mechanical properties. Recent advances …
Liver organ-on-chip models for toxicity studies and risk assessment
T Messelmani, L Morisseau, Y Sakai, C Legallais… - Lab on a Chip, 2022 - pubs.rsc.org
The liver is a key organ that plays a pivotal role in metabolism and ensures a variety of
functions in the body, including homeostasis, synthesis of essential components, nutrient …
functions in the body, including homeostasis, synthesis of essential components, nutrient …
Predicting drug metabolism: experiment and/or computation?
J Kirchmair, AH Göller, D Lang, J Kunze… - Nature reviews Drug …, 2015 - nature.com
Drug metabolism can produce metabolites with physicochemical and pharmacological
properties that differ substantially from those of the parent drug, and consequently has …
properties that differ substantially from those of the parent drug, and consequently has …
Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation
M Vinci, S Gowan, F Boxall, L Patterson… - BMC biology, 2012 - Springer
Background There is overwhelming evidence that in vitro three-dimensional tumor cell
cultures more accurately reflect the complex in vivo microenvironment than simple two …
cultures more accurately reflect the complex in vivo microenvironment than simple two …
Recurrent urinary tract infection: a mystery in search of better model systems
BO Murray, C Flores, C Williams… - Frontiers in cellular …, 2021 - frontiersin.org
Urinary tract infections (UTIs) are among the most common infectious diseases worldwide
but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant …
but are significantly understudied. Uropathogenic E. coli (UPEC) accounts for a significant …
In vitro models for liver toxicity testing
VY Soldatow, EL LeCluyse, LG Griffith… - Toxicology …, 2013 - academic.oup.com
Over the years, various liver-derived in vitro model systems have been developed to enable
investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices …
investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices …