Fanconi anaemia and cancer: an intricate relationship
G Nalepa, DW Clapp - Nature Reviews Cancer, 2018 - nature.com
Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure
(BMF), developmental abnormalities and predisposition to cancer. Together with other …
(BMF), developmental abnormalities and predisposition to cancer. Together with other …
Molecular pathogenesis and clinical management of Fanconi anemia
Y Kee, AD D'Andrea - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
Fanconi anemia (FA) is a rare genetic disorder associated with a high frequency of
hematological abnormalities and congenital anomalies. Based on multilateral efforts from …
hematological abnormalities and congenital anomalies. Based on multilateral efforts from …
Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function
Haematopoietic stem cells (HSCs) regenerate blood cells throughout the lifespan of an
organism. With age, the functional quality of HSCs declines, partly owing to the …
organism. With age, the functional quality of HSCs declines, partly owing to the …
FANCD2 protects against bone marrow injury from ferroptosis
Bone marrow injury remains a serious concern in traditional cancer treatment. Ferroptosis is
an iron-and oxidative-dependent form of regulated cell death that has become part of an …
an iron-and oxidative-dependent form of regulated cell death that has become part of an …
BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair
SF Bunting, E Callén, ML Kozak, JM Kim, N Wong… - Molecular cell, 2012 - cell.com
Brca1 is required for DNA repair by homologous recombination (HR) and normal embryonic
development. Here we report that deletion of the DNA damage response factor 53BP1 …
development. Here we report that deletion of the DNA damage response factor 53BP1 …
TGF-β inhibition rescues hematopoietic stem cell defects and bone marrow failure in Fanconi anemia
H Zhang, DE Kozono, KW O'Connor, S Vidal-Cardenas… - Cell stem cell, 2016 - cell.com
Fanconi anemia (FA) is an inherited DNA repair disorder characterized by progressive bone
marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A greater …
marrow failure (BMF) from hematopoietic stem and progenitor cell (HSPC) attrition. A greater …
[HTML][HTML] Resveratrol counteracts bone loss via mitofilin-mediated osteogenic improvement of mesenchymal stem cells in senescence-accelerated mice
Rational: Senescence of mesenchymal stem cells (MSCs) and the related functional decline
of osteogenesis have emerged as the critical pathogenesis of osteoporosis in aging …
of osteogenesis have emerged as the critical pathogenesis of osteoporosis in aging …
A new frontier in Fanconi anemia: From DNA repair to ribosome biogenesis
A Gueiderikh, F Maczkowiak-Chartois, F Rosselli - Blood reviews, 2022 - Elsevier
Abstract Described by Guido Fanconi almost 100 years ago, Fanconi anemia (FA) is a rare
genetic disease characterized by developmental abnormalities, bone marrow failure (BMF) …
genetic disease characterized by developmental abnormalities, bone marrow failure (BMF) …
Why does the bone marrow fail in Fanconi anemia?
The inherited bone marrow failure (BMF) syndromes are a rare and diverse group of genetic
disorders that ultimately result in the loss of blood production. The molecular defects …
disorders that ultimately result in the loss of blood production. The molecular defects …
Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells
D Carrero, C Soria-Valles… - Disease models & …, 2016 - journals.biologists.com
Ageing is a process that inevitably affects most living organisms and involves the
accumulation of macromolecular damage, genomic instability and loss of heterochromatin …
accumulation of macromolecular damage, genomic instability and loss of heterochromatin …