Melatonin as a natural ally against oxidative stress: a physicochemical examination

A Galano, DX Tan, RJ Reiter - Journal of pineal research, 2011 - Wiley Online Library
Oxidative stress has been proven to be related to the onset of a large number of health
disorders. This chemical stress is triggered by an excess of free radicals, which are …

Pharmacological modulation of Nrf2/HO-1 signaling pathway as a therapeutic target of Parkinson's disease

Y Wang, L Gao, J Chen, Q Li, L Huo, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Parkinson's disease (PD) is a complex neurodegenerative disorder featuring both motor and
nonmotor symptoms associated with a progressive loss of dopaminergic neurons in the …

Functional roles of melatonin in plants, and perspectives in nutritional and agricultural science

DX Tan, R Hardeland, LC Manchester… - Journal of …, 2012 - academic.oup.com
The presence of melatonin in plants is universal. Evidence has confirmed that a major
portion of the melatonin is synthesized by plants themselves even though a homologue of …

Natural products against Alzheimer's disease: Pharmaco-therapeutics and biotechnological interventions

A Dey, R Bhattacharya, A Mukherjee… - Biotechnology advances, 2017 - Elsevier
Alzheimer's disease (AD) is a severe, chronic and progressive neurodegenerative disease
associated with memory and cognition impairment ultimately leading to death. It is the …

Oxidative stress: a suitable therapeutic target for optic nerve diseases?

F Buonfiglio, EW Böhm, N Pfeiffer, A Gericke - Antioxidants, 2023 - mdpi.com
Optic nerve disorders encompass a wide spectrum of conditions characterized by the loss of
retinal ganglion cells (RGCs) and subsequent degeneration of the optic nerve. The etiology …

Alzheimer's disease: pathological mechanisms and the beneficial role of melatonin

SA Rosales‐Corral, D Acuña‐Castroviejo… - Journal of pineal …, 2012 - Wiley Online Library
Alzheimer's disease (AD) is a highly complex neurodegenerative disorder of the aged that
has multiple factors which contribute to its etiology in terms of initiation and progression. This …

Ethnopharmacological approaches for dementia therapy and significance of natural products and herbal drugs

D Tewari, AM Stankiewicz, A Mocan, AN Sah… - Frontiers in aging …, 2018 - frontiersin.org
Dementia is a clinical syndrome wherein gradual decline of mental and cognitive
capabilities of an afflicted person takes place. Dementia is associated with various risk …

Multi-target-directed ligands and other therapeutic strategies in the search of a real solution for Alzheimer's disease

A Agis-Torres, M Sollhuber… - Current …, 2014 - ingentaconnect.com
The lack of an adequate therapy for Alzheimer's Disease (AD) contributes greatly to the
continuous growing amount of papers and reviews, reflecting the important efforts made by …

Melatonin in Alzheimer's disease

L Lin, QX Huang, SS Yang, J Chu, JZ Wang… - International journal of …, 2013 - mdpi.com
Alzheimer's disease (AD), an age-related neurodegenerative disorder with progressive
cognition deficit, is characterized by extracellular senile plaques (SP) of aggregated β …

Neuroprotective effects of cholinesterase inhibitors: current scenario in therapies for Alzheimer's disease and future perspectives

NCS Moreira, JEBF Lima, MF Marchiori… - Journal of …, 2022 - content.iospress.com
Alzheimer's disease (AD) is a slowly progressive neurodegenerative disease
conceptualized as a continuous process, ranging from mild cognitive impairment (MCI), to …