A bibliometric review of drug repurposing

NC Baker, S Ekins, AJ Williams, A Tropsha - Drug discovery today, 2018 - Elsevier
Highlights•A bibliometric review of drug repurposing provides novel insights into the
practice.•Some drugs have been tried in hundreds of diseases.•Even an old drug like …

Metronomic chemotherapy and drug repurposing: A paradigm shift in oncology

N Jan, S Sofi, H Qayoom, A Shabir, BU Haq, MA Macha… - Heliyon, 2024 - cell.com
Cancer represents a significant global health and economic burden due to its high mortality
rates. While effective in some instances, traditional chemotherapy often falls short of entirely …

Targeting the peripheral neural-tumour microenvironment for cancer therapy

D Yaniv, B Mattson, S Talbot, FO Gleber-Netto… - Nature Reviews Drug …, 2024 - nature.com
As the field of cancer neuroscience expands, the strategic targeting of interactions between
neurons, cancer cells and other elements in the tumour microenvironment represents a …

[HTML][HTML] ReDO_DB: the repurposing drugs in oncology database

P Pantziarka, C Verbaanderd, V Sukhatme… - …, 2018 - ncbi.nlm.nih.gov
Repurposing is a drug development strategy that seeks to use existing medications for new
indications. In oncology, there is an increased level of activity looking at the use of non …

Biobehavioral pathways and cancer progression: insights for improving well-being and cancer outcomes

A Chang, EK Sloan, MH Antoni… - Integrative cancer …, 2022 - journals.sagepub.com
The relationship between psychosocial factors and cancer has intrigued people for
centuries. In the last several decades there has been an expansion of mechanistic research …

PEGylated silk nanoparticles for anticancer drug delivery

T Wongpinyochit, P Uhlmann, AJ Urquhart… - …, 2015 - ACS Publications
Silk has a robust clinical track record and is emerging as a promising biopolymer for drug
delivery, including its use as nanomedicine. However, silk-based nanomedicines still …

Vitamin D and regulation of vascular cell function

N Jamali, CM Sorenson… - American Journal of …, 2018 - journals.physiology.org
Vitamin D deficiency is linked to pathogenesis of many diseases including cardiovascular,
cancer, and various eye diseases. In recent years, important roles for vitamin D in regulation …

Metformin and propranolol combination prevents cancer progression and metastasis in different breast cancer models

M Rico, M Baglioni, M Bondarenko, NC Laluce… - …, 2016 - pmc.ncbi.nlm.nih.gov
Discovery of new drugs for cancer treatment is an expensive and time-consuming process
and the percentage of drugs reaching the clinic remains quite low. Drug repositioning refers …

The potential to treat lung cancer via inhalation of repurposed drugs

WH Lee, CY Loo, M Ghadiri, CR Leong… - Advanced drug delivery …, 2018 - Elsevier
Lung cancer is a highly invasive and prevalent disease with ineffective first-line treatment
and remains the leading cause of cancer death in men and women. Despite the …

Repurposing existing therapeutics, its importance in oncology drug development: Kinases as a potential target

S Islam, S Wang, N Bowden, J Martin… - British Journal of …, 2022 - Wiley Online Library
Repurposing the large arsenal of existing non‐cancer drugs is an attractive proposition to
expand the clinical pipelines for cancer therapeutics. The earlier successes in repurposing …