Advanced cell therapies for articular cartilage regeneration

C Madeira, A Santhagunam, JB Salgueiro… - Trends in …, 2015 - cell.com
Advanced cell-based therapies are promising approaches for stimulating full regeneration of
cartilage lesions. In addition to a few commercially available medicinal products, several …

Tissue‐engineered cartilage: The crossroads of biomaterials, cells and stimulating factors

N Bhardwaj, D Devi, BB Mandal - Macromolecular bioscience, 2015 - Wiley Online Library
Damage to cartilage represents one of the most challenging tasks of musculoskeletal
therapeutics due to its limited propensity for healing and regenerative capabilities. Lack of …

Expansion of human mesenchymal stem/stromal cells (hMSCs) in bioreactors using microcarriers: lessons learnt and what the future holds

PS Couto, MC Rotondi, A Bersenev, CJ Hewitt… - Biotechnology …, 2020 - Elsevier
Human mesenchymal stem/stromal cells (hMSCs) present a key therapeutic cellular
intervention for use in cell and gene therapy (CGT) applications due to their …

Scalable microcarrier-based manufacturing of mesenchymal stem/stromal cells

AM de Soure, A Fernandes-Platzgummer… - Journal of …, 2016 - Elsevier
Due to their unique features, mesenchymal stem/stromal cells (MSC) have been exploited in
clinical settings as therapeutic candidates for the treatment of a variety of diseases …

Advanced therapy medicinal products: a guide for bone marrow-derived MSC application in bone and cartilage tissue engineering

D Confalonieri, A Schwab, H Walles… - Tissue Engineering Part …, 2018 - liebertpub.com
Millions of people worldwide suffer from trauma-or age-related orthopedic diseases such as
osteoarthritis, osteoporosis, or cancer. Tissue Engineering (TE) and Regenerative Medicine …

Compositional and structural analysis of glycosaminoglycans in cell-derived extracellular matrices

JC Silva, MS Carvalho, X Han, K **a, PE Mikael… - Glycoconjugate …, 2019 - Springer
The extracellular matrix (ECM) is a highly dynamic and complex meshwork of proteins and
glycosaminoglycans (GAGs) with a crucial role in tissue homeostasis and organization not …

Combination of polyetherketoneketone scaffold and human mesenchymal stem cells from temporomandibular joint synovial fluid enhances bone regeneration

Y Lin, M Umebayashi, MN Abdallah, G Dong… - Scientific reports, 2019 - nature.com
Therapies using human mesenchymal stem cells (MSCs) combined with three-dimensional
(3D) printed scaffolds are a promising strategy for bone grafting. But the harvest of MSCs still …

Integrated culture platform based on a human platelet lysate supplement for the isolation and scalable manufacturing of umbilical cord matrix‐derived mesenchymal …

AM de Soure… - Journal of Tissue …, 2017 - Wiley Online Library
Umbilical cord matrix (UCM)‐derived mesenchymal stem/stromal cells (MSCs) are
promising therapeutic candidates for regenerative medicine settings. UCM MSCs have …

[HTML][HTML] The Myofibroblast Fate of Therapeutic Mesenchymal Stromal Cells: Regeneration, Repair, or Despair?

FS Younesi, B Hinz - International Journal of Molecular Sciences, 2024 - mdpi.com
Mesenchymal stromal cells (MSCs) can be isolated from various tissues of healthy or patient
donors to be retransplanted in cell therapies. Because the number of MSCs obtained from …