The mechanobiology of aging

JM Phillip, I Aifuwa, J Walston… - Annual review of …, 2015 - annualreviews.org
Aging is a complex, multifaceted process that induces a myriad of physiological changes
over an extended period of time. Aging is accompanied by major biochemical and …

Biochemical, structural and physical changes in aging human skin, and their relationship

S Park - Biogerontology, 2022 - Springer
Skin is the largest organ of the human body, having the purpose of regulating temperature,
protecting us from microbes or mechanical shocks, and allowing the sensations from touch …

The local mechanosensitive response of primary cardiac fibroblasts is influenced by the microenvironment mechanics

N Braidotti, G Demontis, M Conti, L Andolfi… - Scientific Reports, 2024 - nature.com
Cardiac fibroblasts (CFs) are essential for preserving myocardial integrity and function. They
can detect variations in cardiac tissue stiffness using various cellular mechanosensors …

The weakness of senescent dermal fibroblasts

L Rebehn, S Khalaji, F KleinJan, A Kleemann… - Proceedings of the …, 2023 - pnas.org
Skin is the largest human organ with easily noticeable biophysical manifestations of aging.
As human tissues age, there is chronological accumulation of biophysical changes due to …

Advanced optical assessment and modeling of extrusion bioprinting

Z Lamberger, DW Schubert, M Buechner… - Scientific Reports, 2024 - nature.com
In the context of tissue engineering, biofabrication techniques are employed to process cells
in hydrogel-based matrices, known as bioinks, into complex 3D structures. The aim is the …

The cellular mechanobiology of aging: from biology to mechanics

A Bajpai, R Li, W Chen - Annals of the New York Academy of …, 2021 - Wiley Online Library
Aging is a chronic, complicated process that leads to degenerative physical and biological
changes in living organisms. Aging is associated with permanent, gradual physiological …

[PDF][PDF] An overview of factors affecting the skins Youngs modulus

A Kalra, A Lowe, AA Jumaily - J. Aging Sci, 2016 - researchgate.net
Skin is the outermost layer of the human body which regulates the body temperature and
protects the body from abrasion and water loss. The Young's Modulus of skin is measured …

Sex-and age-dependent skin mechanics—A detailed look in mice

CY Lin, GP Sugerman, S Kakaletsis, WD Meador… - Acta Biomaterialia, 2024 - Elsevier
Skin aging is of immense societal and, thus, scientific interest. Because mechanics play a
critical role in skin's function, a plethora of studies have investigated age-induced changes …

[HTML][HTML] Vimentin plays a crucial role in fibroblast ageing by regulating biophysical properties and cell migration

K Sliogeryte, N Gavara - Cells, 2019 - mdpi.com
Ageing is the result of changes in biochemical and biophysical processes at the cellular
level that lead to progressive organ decline. Here we focus on the biophysical changes that …

Stiffness and aging in cardiovascular diseases: the dangerous relationship between force and senescence

S Ferrari, M Pesce - International Journal of Molecular Sciences, 2021 - mdpi.com
Biological aging is a process associated with a gradual decline in tissues' homeostasis
based on the progressive inability of the cells to self-renew. Cellular senescence is one of …