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Diffuse glioma heterogeneity and its therapeutic implications
JG Nicholson, HA Fine - Cancer discovery, 2021 - aacrjournals.org
Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors
characterized by minimally effective genotype-targeted therapies. Recent advances have …
characterized by minimally effective genotype-targeted therapies. Recent advances have …
Glioblastoma stem cells: driving resilience through chaos
Glioblastoma is an aggressive and heterogeneous tumor in which glioblastoma stem cells
(GSCs) are at the apex of an entropic hierarchy and impart devastating therapy resistance …
(GSCs) are at the apex of an entropic hierarchy and impart devastating therapy resistance …
Glioma stem cells and their roles within the hypoxic tumor microenvironment
Tumor microenvironments are the result of cellular alterations in cancer that support
unrestricted growth and proliferation and result in further modifications in cell behavior …
unrestricted growth and proliferation and result in further modifications in cell behavior …
The role of glioma stem cells in chemotherapy resistance and glioblastoma multiforme recurrence
Glioma stem cells (GSCs) constitute a slow-dividing, small population within a
heterogeneous glioblastoma. They are able to self-renew, recapitulate a whole tumor, and …
heterogeneous glioblastoma. They are able to self-renew, recapitulate a whole tumor, and …
Targeting glioblastoma stem cells: a review on biomarkers, signal pathways and targeted therapy
X Tang, C Zuo, P Fang, G Liu, Y Qiu, Y Huang… - Frontiers in …, 2021 - frontiersin.org
Glioblastoma (GBM) remains the most lethal and common primary brain tumor, even after
treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation …
treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation …
The ZEB1 pathway links glioblastoma initiation, invasion and chemoresistance
Glioblastoma remains one of the most lethal types of cancer, and is the most common brain
tumour in adults. In particular, tumour recurrence after surgical resection and radiation …
tumour in adults. In particular, tumour recurrence after surgical resection and radiation …
Pharmacological inhibition of BACE1 suppresses glioblastoma growth by stimulating macrophage phagocytosis of tumor cells
Glioblastoma (GBM) contains abundant tumor-associated macrophages (TAMs). The
majority of TAMs are tumor-promoting macrophages (pTAMs), while tumor-suppressive …
majority of TAMs are tumor-promoting macrophages (pTAMs), while tumor-suppressive …
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2
Tumors reprogram their metabolism to generate complex neoplastic ecosystems. Here, we
demonstrate that glioblastoma (GBM) stem cells (GSCs) display elevated activity of the …
demonstrate that glioblastoma (GBM) stem cells (GSCs) display elevated activity of the …
Interleukins in glioblastoma pathophysiology: implications for therapy
YT Yeung, KL McDonald, T Grewal… - British journal of …, 2013 - Wiley Online Library
Despite considerable amount of research, the poor prognosis of patients diagnosed with
glioblastoma multiforme (GBM) critically needs new drug development to improve clinical …
glioblastoma multiforme (GBM) critically needs new drug development to improve clinical …
Role of exosomes in malignant glioma: microRNAs and proteins in pathogenesis and diagnosis
Malignant gliomas are the most common and deadly type of central nervous system tumors.
Despite some advances in treatment, the mean survival time remains only about 1.25 years …
Despite some advances in treatment, the mean survival time remains only about 1.25 years …