Quantum computing holds substantial potential for applications in biology and medicine,
spanning from the simulation of biomolecules to machine learning methods for subty** …

The physical microenvironment of cancer is characterized by elevated stiffness and tissue
pressure, the main component of which is the interstitial fluid pressure (IFP). Elevated IFP is …

Delivery of chemotherapeutic medicines to solid tumors is critical for optimal therapeutic
success and minimal adverse effects. We mathematically developed a delivery method …

As cancer progresses, a dynamic microenvironment develops that creates and responds to
cellular and biophysical cues. Increased intratumoral pressure and corresponding increases …

Nano-based drug delivery systems hold significant promise for cancer therapies. Presently,
the poor accumulation of drug-carrying nanoparticles in tumors has limited their success. In …

Dermal interstitial fluid (ISF) is a novel source of biomarkers that can be considered as an
alternative to blood sampling for disease diagnosis and treatment. Nevertheless, in vivo …

The complicated capillary network induced by angiogenesis is one of the main reasons of
unsuccessful cancer therapy. A multi-scale mathematical method which simulates drug …

Convection-enhanced delivery (CED) is a method used to increase transport of therapeutics
in and around brain tumors. CED works through locally applying a pressure differential to …

Understanding the uptake of a drug by diseased tissue, and the drug's subsequent
spatiotemporal distribution, are central factors in the development of effective targeted …

A deeper understanding of the tumor microenvironment (TME) and its role in metabolic
activity at different stages of vascularized tumors can provide useful insights into cancer …