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Mechanics and functional consequences of nuclear deformations
As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …
fate and function in response to various signals and stimuli. In addition to biochemical …
Mechanosensing by the nucleus: From pathways to scaling relationships
Tissue physical properties depend on the cells that make the tissue and also seem to be
affected by tissue use. For example, muscle, cartilage, and bone, when suitably exercised …
affected by tissue use. For example, muscle, cartilage, and bone, when suitably exercised …
Nuclear positioning facilitates amoeboid migration along the path of least resistance
During metazoan development, immune surveillance and cancer dissemination, cells
migrate in complex three-dimensional microenvironments,–. These spaces are crowded by …
migrate in complex three-dimensional microenvironments,–. These spaces are crowded by …
Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus
The cell nucleus must continually resist and respond to intercellular and intracellular
mechanical forces to transduce mechanical signals and maintain proper genome …
mechanical forces to transduce mechanical signals and maintain proper genome …
Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins
Nuclear shape and architecture influence gene localization, mechanotransduction,
transcription, and cell function. Abnormal nuclear morphology and protrusions termed …
transcription, and cell function. Abnormal nuclear morphology and protrusions termed …
Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation
Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …
Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations
Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …
The lamin protein family
The lamins are the major architectural proteins of the animal cell nucleus. Lamins line the
inside of the nuclear membrane, where they provide a platform for the binding of proteins …
inside of the nuclear membrane, where they provide a platform for the binding of proteins …
[HTML][HTML] Nuclear mechanics and mechanotransduction in health and disease
The nucleus is the defining feature of eukaryotic cells and often represents the largest
organelle. Over the past decade, it has become apparent that the nucleus is tightly …
organelle. Over the past decade, it has become apparent that the nucleus is tightly …
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin
Over the past few years it has become evident that the intermediate filament proteins, the
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but …
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but …