The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Pain is a sensory state resulting from complex integration of peripheral nociceptive inputs
and central processing. Pain consists of adaptive pain that is acute and beneficial for …

Neuropathic pain refers to a variety of chronic pain conditions with differing underlying
pathophysiologic mechanisms and origins. Recent studies indicate a communication …

Many studies support the pro-nociceptive role of brain-derived neurotrophin factor (BDNF) in
pain processes in the peripheral and central nervous system. We have previously shown …

The primary sensory neurons that respond to noxious stimulation and project to the spinal
cord are known to fall into two distinct groups: one sensitive to nerve growth factor and the …

Brain‐derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family of
signaling molecules. Since its discovery over three decades ago, BDNF has been identified …

Obesity, which is assuming alarming proportions, has been attributed to genetic factors,
hypothalamic dysfunction, and intestinal gut bacteria and an increase in the consumption of …

Neurotrophic factors, which support neuronal survival and growth during development of the
nervous system, have been shown to play significant roles in the transmission of physiologic …

While spinal microglia play a role in early stages of neuropathic pain etiology, whether they
are useful targets to reverse chronic pain at late stages remains unknown. Here, we show …

BACKGROUND: Bone cancer pain is very common, and patients with this type of pain may
be difficult to treat. Development of an experimental model for studying this condition is …