Hypoxia is a physiological cue that impacts diverse physiological processes, including
energy metabolism, autophagy, cell motility, angiogenesis, and erythropoiesis. One of the …

Transcription factors of the MYC family are deregulated in the majority of all human cancers.
Oncogenic levels of MYC reprogram cellular metabolism, a hallmark of cancer development …

Hypoxia exerts a profound impact on diverse aspects of cancer biology. Increasing evidence
has revealed novel functions of hypoxia in cancer cell epigenomics, epitranscriptomics …

Simple Summary Hypoxia is defined as the inadequate supply of oxygen in tissues. Regions
of acute and chronic hypoxia are a universal feature of the tumor microenvironment and a …

The transcription factor c-MYC (MYC thereafter) is a global regulator of gene expression. It is
overexpressed or deregulated in human cancers of diverse origins and plays a key role in …

Abstract Development of malignancy is accompanied by a complete metabolic
reprogramming closely related to the acquisition of most of cancer hallmarks. In fact, key …

Eukaryotes are often subjected to different kinds of stress. In order to adjust to such
circumstances, eukaryotes activate stress–response pathways and regulate gene …

Despite the fact that great advances have been made in the management of non-small cell
lung cancer (NSCLC), the prognosis of advanced NSCLC remains very poor. HOX transcript …

Cellular adaptation to hypoxia is a hallmark of cancer, but the relative contribution of hypoxia-
inducible factors (HIFs) versus other oxygen sensors to tumorigenesis is unclear. We employ …

The integrity of the basal stem cell layer is critical for epithelial homoeostasis. In this paper,
we review the expression of oral mucosal stem cell markers (OM-SCMs) in oral submucous …