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A guide to adaptive immune memory
N Lam, YS Lee, DL Farber - Nature Reviews Immunology, 2024 - nature.com
Immune memory—comprising T cells, B cells and plasma cells and their secreted antibodies—
is crucial for human survival. It enables the rapid and effective clearance of a pathogen after …
is crucial for human survival. It enables the rapid and effective clearance of a pathogen after …
Challenges and opportunities for consistent classification of human B cell and plasma cell populations
I Sanz, C Wei, SA Jenks, KS Cashman… - Frontiers in …, 2019 - frontiersin.org
The increasingly recognized role of different types of B cells and plasma cells in protective
and pathogenic immune responses combined with technological advances have generated …
and pathogenic immune responses combined with technological advances have generated …
[HTML][HTML] Pan-cancer single-cell dissection reveals phenotypically distinct B cell subtypes
Y Yang, X Chen, J Pan, H Ning, Y Zhang, Y Bo, X Ren… - Cell, 2024 - cell.com
Characterizing the compositional and phenotypic characteristics of tumor-infiltrating B cells
(TIBs) is important for advancing our understanding of their role in cancer development …
(TIBs) is important for advancing our understanding of their role in cancer development …
Distinct effector B cells induced by unregulated toll-like receptor 7 contribute to pathogenic responses in systemic lupus erythematosus
SA Jenks, KS Cashman, E Zumaquero, UM Marigorta… - Immunity, 2018 - cell.com
Summary Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …
CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5 …
IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE
S Wang, J Wang, V Kumar, JL Karnell… - Nature …, 2018 - nature.com
Although the aetiology of systemic lupus erythematosus (SLE) is unclear, dysregulated B
cell responses have been implicated. Here we show that an unusual CD11chiT-bet+ B cell …
cell responses have been implicated. Here we show that an unusual CD11chiT-bet+ B cell …
Zeb2 drives the formation of CD11c+ atypical B cells to sustain germinal centers that control persistent infection
X Gao, Q Shen, JA Roco, B Dalton, K Frith… - Science …, 2024 - science.org
CD11c+ atypical B cells (ABCs) are an alternative memory B cell lineage associated with
immunization, infection, and autoimmunity. However, the factors that drive the transcriptional …
immunization, infection, and autoimmunity. However, the factors that drive the transcriptional …
[HTML][HTML] An integrated multi-omic single-cell atlas of human B cell identity
B cells are capable of a wide range of effector functions including antibody secretion,
antigen presentation, cytokine production, and generation of immunological memory. A …
antigen presentation, cytokine production, and generation of immunological memory. A …
The expansion of human T-bethighCD21low B cells is T cell dependent
B Keller, V Strohmeier, I Harder, S Unger… - Science …, 2021 - science.org
Accumulation of human CD21low B cells in peripheral blood is a hallmark of chronic
activation of the adaptive immune system in certain infections and autoimmune disorders …
activation of the adaptive immune system in certain infections and autoimmune disorders …
Atypical B cells are part of an alternative lineage of B cells that participates in responses to vaccination and infection in humans
The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing
(RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy …
(RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy …
Early B cell changes predict autoimmunity following combination immune checkpoint blockade
Combination checkpoint blockade (CCB) targeting inhibitory CTLA4 and PD1 receptors
holds promise for cancer therapy. Immune-related adverse events (IRAEs) remain a major …
holds promise for cancer therapy. Immune-related adverse events (IRAEs) remain a major …