Oxygen-derived free radicals and related oxidants are ubiquitous and short-lived
intermediates formed in aerobic organisms throughout life. These reactive species …

Peroxynitrite is a short-lived and reactive biological oxidant formed from the diffusion-
controlled reaction of the free radicals superoxide (O2•–) and nitric oxide (• NO). In this …

The discovery that mammalian cells generate nitric oxide, a gas previously considered to be
merely an atmospheric pollutant, is providing important information about many biologic …

Three isozymes of nitric oxide (NO) synthase (EC 1.14. 13.39) have been identified and the
cDNAs for these enzymes isolated. In humans, isozymes I (in neuronal and epithelial cells) …

The recent discovery of nitric oxide ('NO)'as a mammalian metabolic intermediate has
exploded into a swiftly develo** area of research. The intense interest and rapid progress …

Superoxide (O2-.), nitric oxide (. NO), and their reaction product peroxynitrite (ONOO-) have
all been shown to independently exert toxic target molecule reactions. Because these …

Infection by bacteria, parasites or viruses and tissue inflammation such as gastritis, hepatitis
and colitis are recognized risk factors for human cancers at various sites. Nitric oxide (NO) …

Nitric oxide (NO) was initially described as a physiological mediator of endothelial cell
relaxation, an important role in hypotension. NO is an intercellular messenger that has been …

Cyclooxygenase (COX) converts arachidonic acid to prostaglandin H2, which is further
metabolized to prostanoids. Two isoforms of COX exist: a constitutive (COX-1) and an …

Mice deficient in inducible nitric oxide synthase (iNOS) were generated to test the idea that!
NOS defends the host against infectious agents and tumor cells at the risk of contributing to …