The role of melanoma cell-stroma interaction in cell motility, invasion, and metastasis
The importance of studying cancer cell invasion is highlighted by the fact that 90% of all
cancer-related mortalities are due to metastatic disease. Melanoma metastasis is driven …
cancer-related mortalities are due to metastatic disease. Melanoma metastasis is driven …
Decoding molecular programs in melanoma brain metastases
J Radke, E Schumann, J Onken, R Koll, G Acker… - Nature …, 2022 - nature.com
Melanoma brain metastases (MBM) variably respond to therapeutic interventions; thus
determining patient's prognosis. However, the mechanisms that govern therapy response …
determining patient's prognosis. However, the mechanisms that govern therapy response …
RAC1mutation is not a predictive biomarker for PI3'‐kinase‐β‐selective pathway‐targeted therapy
Mutational activation of RAC1 is detected in~ 7% of cutaneous melanoma, with the most
frequent mutation (RAC1C85T) encoding for RAC1P29S. RAC1P29S is a fast‐cycling …
frequent mutation (RAC1C85T) encoding for RAC1P29S. RAC1P29S is a fast‐cycling …
Mutant p53 triggers a dynamin-1/APPL1 endosome feedback loop that regulates β1 integrin recycling and migration
Multiple mechanisms contribute to cancer cell progression and metastatic activity, including
changes in endocytic trafficking and signaling of cell surface receptors. We report that gain …
changes in endocytic trafficking and signaling of cell surface receptors. We report that gain …
[CARTE][B] The P-REX2 and FLII signalling axis in melanoma
GM Davis - 2020 - search.proquest.com
RAC1 GEFs have been shown to be capable of determining the signalling outputs of RAC1
signalling, specifically P-REX1 has been shown to interact with and facilitate RAC1 …
signalling, specifically P-REX1 has been shown to interact with and facilitate RAC1 …