Integrated lncRNA function upon genomic and epigenomic regulation

AB Herman, D Tsitsipatis, M Gorospe - Molecular Cell, 2022 - cell.com
Although some long noncoding (lnc) RNAs are known since the 1950s, the past 25 years
have uncovered myriad lncRNAs with diverse sequences, structures, and functions. The …

[HTML][HTML] Gene regulation by long non-coding RNAs and its biological functions

L Statello, CJ Guo, LL Chen, M Huarte - Nature reviews Molecular cell …, 2021 - nature.com
Evidence accumulated over the past decade shows that long non-coding RNAs (lncRNAs)
are widely expressed and have key roles in gene regulation. Recent studies have begun to …

New insights into the interplay between long non‐coding RNAs and RNA‐binding proteins in cancer

ZT Yao, YM Yang, MM Sun, Y He, L Liao… - Cancer …, 2022 - Wiley Online Library
With the development of proteomics and epigenetics, a large number of RNA‐binding
proteins (RBPs) have been discovered in recent years, and the interaction between long …

The role of non-coding RNAs in oncology

FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

[HTML][HTML] Emerging roles of lncRNA in cancer and therapeutic opportunities

MC Jiang, JJ Ni, WY Cui, BY Wang… - American journal of …, 2019 - ncbi.nlm.nih.gov
Cancer is difficult to cure due to frequent metastasis, and develo** effective therapeutic
approaches to treat cancer is urgently important. Long non-coding RNAs (lncRNAs) have …

Long non-coding RNAs: the regulatory mechanisms, research strategies, and future directions in cancers

N Gao, Y Li, J Li, Z Gao, Z Yang, Y Li, H Liu… - Frontiers in …, 2020 - frontiersin.org
The development and application of whole genome sequencing technology has greatly
broadened our horizons on the capabilities of long non-coding RNAs (lncRNAs). LncRNAs …

Tumor immune microenvironment lncRNAs

EG Park, SJ Pyo, Y Cui, SH Yoon… - Briefings in …, 2022 - academic.oup.com
Long non-coding ribonucleic acids (RNAs)(lncRNAs) are key players in tumorigenesis and
immune responses. The nature of their cell type-specific gene expression and other …

LncRNA-mediated regulation of cell signaling in cancer

WX Peng, P Koirala, YY Mo - Oncogene, 2017 - nature.com
To date, a large number of long non-coding RNAs (lncRNAs) have been recently discovered
through functional genomics studies. Importantly, lncRNAs have been shown, in many …

History, discovery, and classification of lncRNAs

J Jarroux, A Morillon, M Pinskaya - Long non coding RNA biology, 2017 - Springer
Abstract The RNA World Hypothesis suggests that prebiotic life revolved around RNA
instead of DNA and proteins. Although modern cells have changed significantly in 4 billion …

Non-coding RNAs and potential therapeutic targeting in cancer

S Toden, TJ Zumwalt, A Goel - … et Biophysica Acta (BBA)-Reviews on …, 2021 - Elsevier
Recent advances have begun to clarify the physiological and pathological roles of non-
coding RNAs (ncRNAs) in various diseases, including cancer. Among these, microRNAs …