Social behaviors, how individuals act cooperatively and competitively with conspecifics, are
widely seen across species. Rodents display various social behaviors, and many different …

Major depression is a leading contributor to the global burden of disease. This situation is
mainly related to the chronicity and/or recurrence of the disorder, and to poor response to …

Our understanding of depression and its treatment has advanced with the advent of
ketamine as a rapid-acting antidepressant and the development and refinement of tools …

The medial prefrontal cortex (mPFC) is a crucial cortical region that integrates information
from numerous cortical and subcortical areas and converges updated information to output …

Although the etiology and expression of psychiatric disorders are complex, mammals show
biologically preserved behavioral and neurobiological responses to valent stimuli which …

N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP),
dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia …

Ketamine, a non-competitive antagonist of N-methyl-D-aspartate (NMDA) receptor, displays
a fast antidepressant activity in treatment-resistant depression and in rodent models of …

Background Depression is the most common mental illness. Mounting evidence suggests
that dysregulation of extracellular ATP (adenosine triphosphate) is involved in the …

Social behavior encompasses a number of distinctive and complex constructs that form the
core elements of human imitative culture, mainly represented as either affiliative or …

Background The nucleus accumbens is a critical mediator of depression-related outcomes
to social defeat stress. Previous studies demonstrate distinct neuroplasticity adaptations in …