Circulating blood monocytes supply peripheral tissues with macrophage and dendritic cell
(DC) precursors and, in the setting of infection, also contribute directly to immune defense …

Publisher Summary This chapter focuses on interleukin-8 (IL-8) and related chemotactic
cytokines—namely, CXC and CC chemokines. IL-8 is the best known member of a new …

Damage of the endothelial glycocalyx, which ranges from 200 to 2000 nm in thickness,
decreases vascular barrier function and leads to protein extravasation and tissue oedema …

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the isoenzymes COX-1 and COX-2 of
cyclooxygenase (COX). Renal side effects (eg, kidney function, fluid and urinary electrolyte …

Organisms survive by maintaining equilibrium with their environment. The stress system is
critical to this homeostasis. Glucocorticoids modulate the stress response at a molecular …

Background Sepsis refers to the dysregulated host immune response elicited by microbial
infections resulting in life-threatening organ dysfunction. Sepsis represents a medical …

Glucocorticoids and interleukin 10 (IL-10) prevent macrophage activation. In murine
lymphocytes, glucocorticoids induce expression of glucocorticoid-induced leucine zipper …

A glucocorticoid, dexamethasone, inhibited the production of a leukocyte chemotactic
cytokine, interleukin 8 (IL-8), as well as mRNA expression by a glioblastoma cell line, T98G …

Background Hydrocortisone protects against ischemia-reperfusion injury, reduces
paracellular permeability for macromolecules, and is routinely applied in the prevention of …

There is a broad consensus that glucocorticoids (GCs) exert anti-inflammatory effects largely
by inhibiting the function of nuclear factor κB (NFκB) and consequently the transcription of …