Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

Autosomal recessive primary microcephaly (MCPH) is a neurodevelopmental disorder that
is characterised by microcephaly present at birth and non-progressive mental retardation …

Accurate chromosome segregation requires carefully regulated interactions between
kinetochores and microtubules, but how plasticity is achieved to correct diverse attachment …

Kinetochores are large protein assemblies built on chromosomal loci named centromeres.
The main functions of kinetochores can be grouped under four modules. The first module, in …

Regulated interactions between kinetochores and spindle microtubules are essential to
maintain genomic stability during chromosome segregation. The Aurora B kinase …

The accurate segregation of chromosomes during mitosis is essential for the reproduction
and development of all organisms. Defects in chromosome segregation can cause cell …

Defining the genes that are essential for cellular proliferation is critical for understanding
organismal development and identifying high-value targets for disease therapies. However …

Tumor cells frequently exhibit widespread epigenetic aberrations that significantly alter the
repertoire of expressed proteins. In particular, it has been known for nearly 25 years that …

Chromosomal instability (CIN) is a hallmark of cancer that contributes to tumour
heterogeneity and other malignant properties. Aberrant centromere and kinetochore function …

Since the ancestors of modern humans separated from those of Neanderthals, around 100
amino acid substitutions spread to essentially all modern humans. The biological …