An overview of quinazolines: Pharmacological significance and recent developments
V Alagarsamy, K Chitra, G Saravanan… - European journal of …, 2018 - Elsevier
Most of the drugs and pharmacologically relevant molecules possess heterocyclic ring
structures and presence of hetero atoms or grou**s divulges privileged specificities in …
structures and presence of hetero atoms or grou**s divulges privileged specificities in …
Glioma-targeted therapeutics: computer-aided drug design prospective
Amongst the several types of brain cancers known to humankind, glioma is one of the most
severe and life-threatening types of cancer, comprising 40% of all primary brain tumors …
severe and life-threatening types of cancer, comprising 40% of all primary brain tumors …
Computational identification of 2, 4-disubstituted amino-pyrimidines as L858R/T790M-EGFR double mutant inhibitors using pharmacophore map**, molecular …
Pharmacophore modelling studies have been performed for a series of 2, 4-disubstituted-
pyrimidines derivatives as EGFR L858R/T790M tyrosine kinase inhibitors. The high scoring …
pyrimidines derivatives as EGFR L858R/T790M tyrosine kinase inhibitors. The high scoring …
Develo** multitarget coumarin based anti-breast cancer agents: synthesis and molecular modeling study
A new series of 7-substituted coumarin scaffolds containing a methyl ester moiety at the C4-
position were synthesized and tested for their in vitro anti-proliferative activity against MCF-7 …
position were synthesized and tested for their in vitro anti-proliferative activity against MCF-7 …
GraphEGFR: Multi‐task and transfer learning based on molecular graph attention mechanism and fingerprints improving inhibitor bioactivity prediction for EGFR family …
B Boonyarit, N Yamprasert… - Journal of …, 2024 - Wiley Online Library
The proteins within the human epidermal growth factor receptor (EGFR) family, members of
the tyrosine kinase receptor family, play a pivotal role in the molecular mechanisms driving …
the tyrosine kinase receptor family, play a pivotal role in the molecular mechanisms driving …
Fe 3 O 4@ Sap/Cu (ii): an efficient magnetically recoverable green nanocatalyst for the preparation of acridine and quinazoline derivatives in aqueous media at room …
Saponin, as a green and available phytochemical, was immobilized on the surface of
magnetite nanoparticles then doped with Cu ions (Fe3O4@ Sap/Cu (II)) and used as an …
magnetite nanoparticles then doped with Cu ions (Fe3O4@ Sap/Cu (II)) and used as an …
Field and atom-based 3D-QSAR models of chromone (1-benzopyran-4-one) derivatives as MAO inhibitors
Monoamine oxidases (MAOs) are flavo-enzymes that aid in the oxidative deamination of
neurotransmitters like dopamine, serotonin, and epinephrine. MAO inhibitors are …
neurotransmitters like dopamine, serotonin, and epinephrine. MAO inhibitors are …
Synthesis, thymidine phosphorylase inhibitory and computational study of novel 1, 3, 4-oxadiazole-2-thione derivatives as potential anticancer agents
S Bajaj, PP Roy, J Singh - Computational Biology and Chemistry, 2018 - Elsevier
Abstract A series of novel 1, 3, 4-oxadiazole-2-thione derivatives were designed,
synthesized and evaluated for in vitro anticancer activity against breast cancer (MCF-7) cell …
synthesized and evaluated for in vitro anticancer activity against breast cancer (MCF-7) cell …
Investigation of sphingosine kinase 1 inhibitory potential of cinchonine and colcemid targeting anticancer therapy
S Roy, S Khan, DS Jairajpuri, A Hussain… - Journal of …, 2022 - Taylor & Francis
Abstract Sphingosine kinase 1 (SphK1) and sphingosine-1-phosphate (S1P) signaling
regulates numerous diseases such as cancer, diabetes, and inflammation-related ailments …
regulates numerous diseases such as cancer, diabetes, and inflammation-related ailments …
Identification of novel curcumin derivatives against pancreatic cancer: a comprehensive approach integrating 3D-QSAR pharmacophore modeling, virtual screening …
Pancreatic cancer, known as the “silent killer,” poses a daunting challenge in cancer
therapy. The dysregulation of the PI3Kα signaling pathway in pancreatic cancer has …
therapy. The dysregulation of the PI3Kα signaling pathway in pancreatic cancer has …