Roles of polyamines in translation

TE Dever, IP Ivanov - Journal of Biological Chemistry, 2018 - ASBMB
Polyamines are organic polycations that bind to a variety of cellular molecules, including
nucleic acids. Within cells, polyamines contribute to both the efficiency and fidelity of protein …

Role of polyamines and hypusine in β cells and diabetes pathogenesis

A Kulkarni, CM Anderson, RG Mirmira, SA Tersey - Metabolites, 2022 - mdpi.com
The polyamines—putrescine, spermidine, and spermine—are polycationic, low molecular
weight amines with cellular functions primarily related to mRNA translation and cell …

Pan-cancer analysis of transcriptional metabolic dysregulation using The Cancer Genome Atlas

SR Rosario, MD Long, HC Affronti, AM Rowsam… - Nature …, 2018 - nature.com
Understanding metabolic dysregulation in different disease settings is vital for the safe and
effective incorporation of metabolism-targeted therapeutics in the clinic. Here, using …

Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing

J Kang, DI Benjamin, S Kim, JS Salvi, G Dhaliwal… - Nature …, 2024 - nature.com
The global loss of heterochromatin during ageing has been observed in eukaryotes from
yeast to humans, and this has been proposed as one of the causes of ageing. However, the …

A bibliography study of Shewanella oneidensis biofilm

S Chen, Y Ding - FEMS Microbiology Ecology, 2023 - academic.oup.com
This study employs a bibliography study method to evaluate 472 papers focused on
Shewanella oneidensis biofilms. Biofilms, which are formed when microorganisms adhere to …

[LIBRO][B] Feedback control in systems biology

C Cosentino, D Bates - 2011 - books.google.com
Like engineering systems, biological systems must also operate effectively in the presence
of internal and external uncertainty—such as genetic mutations or temperature changes, for …

Polyamine sensing by nascent ornithine decarboxylase antizyme stimulates decoding of its mRNA

L Kurian, R Palanimurugan, D Gödderz, RJ Dohmen - Nature, 2011 - nature.com
Polyamines are essential organic polycations with multiple cellular functions relevant for cell
division, cancer and ageing,,. Regulation of polyamine synthesis is mainly achieved by …

Monitoring translation in all reading frames downstream of weak stop codons provides mechanistic insights into the impact of nucleotide and cellular contexts

G Loughran, X Li, S O'Loughlin, JF Atkins… - Nucleic Acids …, 2023 - academic.oup.com
A stop codon entering the ribosome A-site is normally decoded by release factors that
induce release of the polypeptide. Certain factors influence the efficiency of the termination …

[HTML][HTML] Obesity-associated colorectal cancer

L Gonzalez-Gutierrez, O Motiño, D Barriuso… - International Journal of …, 2024 - mdpi.com
Colorectal cancer (CRC) affects approximately 2 million people worldwide. Obesity is the
major risk factor for CRC. In addition, obesity contributes to a chronic inflammatory stage that …

Plasma and urine metabolite profiles impacted by increased dietary navy bean intake in colorectal cancer survivors: a randomized-controlled trial

I Zarei, BA Baxter, RC Oppel, EC Borresen… - Cancer Prevention …, 2021 - AACR
Navy beans contain bioactive phytochemicals with colon cancer prevention properties as
demonstrated in carcinogen-induced animal models. Human studies support that dietary …